Results 141 to 150 of about 8,087 (328)

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

open access: yesCell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo   +4 more
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

Estimating surface temperature in forced convection nucleate boiling: A simplified method [PDF]

open access: yes
During a test program to investigate low-cycle thermal fatigue, 21 of 22 cylindrical test sections of a cylindrical rocket thrust chamber were thermally cycled to failure. Cylinder liners were fabricated from OFHC copper, Amzirc, and NARloy-Z.
Hendricks, R. C., Papell, S. S.
core   +1 more source

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

open access: yesThe FEBS Journal, EarlyView.
The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause   +5 more
wiley   +1 more source

Extended hydrodynamic theory of the peak and minimum pool boiling heat fluxes [PDF]

open access: yes
The hydrodynamic theory of the extreme pool boiling heat fluxes is expanded to embrace a variety of problems that have not previously been analyzed. These problems include the prediction of the peak heat flux on a variety of finite heaters, the influence
Dhir, V. K., Linehard, J. H.
core   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

open access: yesThe FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio   +12 more
wiley   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

open access: yesThe FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez   +7 more
wiley   +1 more source

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