Results 1 to 10 of about 6,071,343 (411)

Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA

Nature Methods, 2023
Protein–RNA and protein–DNA complexes play critical roles in biology. Despite considerable recent advances in protein structure prediction, the prediction of the structures of protein–nucleic acid complexes without homology to known complexes is a ...
M. Baek, Ryan McHugh, I. Anishchenko, Hanlun Jiang, David Baker, F. DiMaio   +5 more
semanticscholar   +1 more source

Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Journal of Nanobiotechnology, 2022
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity
Ying Zhang, Qiqi Liu, Xinmeng Zhang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Zhourui Xu, Meirong Li, Xin Chen, Jia Liu, Chengbin Yang   +10 more
semanticscholar   +1 more source

The current landscape of nucleic acid therapeutics

Nature Nanotechnology, 2021
The increasing number of approved nucleic acid therapeutics demonstrates the potential to treat diseases by targeting their genetic blueprints in vivo.
J. Kulkarni, D. Witzigmann, Sarah B. Thomson, Sam Chen, B. Leavitt, P. Cullis, R. van der Meel   +6 more
semanticscholar   +1 more source

Rapid clonal identification of biallelic CRISPR/Cas9 knock-ins using SNEAK PEEC

Scientific Reports, 2023
One of the challenges faced by current CRISPR/Cas9 editing strategies is the difficulty in rapidly selecting clonal populations of biallelically edited cells.
Sameer Singh, Anoosha Banerjee, Arnaud Vanden Broeck, Sebastian Klinge   +3 more
doaj   +1 more source

Serpentine and Vermiform Are Produced Autonomously to Fulfill Their Function in Drosophila Wings

Insects, 2023
Group I chitin deacetylases (CDAs), CDA1 and CDA2, play an essential role in cuticle formation and molting in the process of insect wing development. A recent report showed that trachea are able to take up a secreted CDA1 (serpentine, serp) produced in ...
Xubo Zhang, Yanan Ji, Bernard Moussian, Shumin Yang, Jianzhen Zhang, Tingting Zhang, Min Zhang   +6 more
doaj   +1 more source

Prevalence of Dengue, Chikungunya and Zika Viruses in Blood Donors in the State of Pará, Northern Brazil: 2018–2020

Medicina, 2022
Arboviruses have been reported over the years as constant threats to blood transfusion recipients, given the high occurrence of asymptomatic cases and the fact that the presence of viremia precedes the onset of symptoms, making it possible that infected ...
Leticia Martins Lamarão, Angelita Silva Miranda Corrêa, Renata Bezerra Hermes de Castro, Carlos Eduardo de Melo Amaral, Patricia Danin Jordão Monteiro, Mauricio Koury Palmeira, Luane Nascimento Lopes, Angela Neves Oliveira, Maria Salete Maciel de Lima, Caroline Aquino Moreira-Nunes, Rommel Rodríguez Burbano   +10 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Specificity Determination in Saccharomyces cerevisiae Killer Virus Systems

Microorganisms, 2021
Saccharomyces yeasts are widely distributed in the environment and microbiota of higher organisms. The killer phenotype of yeast, encoded by double-stranded RNA (dsRNA) virus systems, is a valuable trait for host survival. The mutual relationship between
Lina Aitmanaitė, Aleksandras Konovalovas, Povilas Medvedevas, Elena Servienė, Saulius Serva   +4 more
doaj   +1 more source

Regulation of the nucleic acid-sensing Toll-like receptors

Nature reviews. Immunology, 2021
Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that receptor activation unequivocally indicates the presence of something foreign.
Nicholas A. Lind, Victoria E. Rael, K. Pestal, Bo Liu, G. Barton   +4 more
semanticscholar   +1 more source

Non-canonical DNA structures: Diversity and disease association

Frontiers in Genetics, 2022
A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA.
Aparna Bansal, Aparna Bansal, Shikha Kaushik, Shikha Kaushik, Shrikant Kukreti   +4 more
doaj   +1 more source