Results 1 to 10 of about 745,151 (268)
Rapid clonal identification of biallelic CRISPR/Cas9 knock-ins using SNEAK PEEC
Scientific Reports, 2023 One of the challenges faced by current CRISPR/Cas9 editing strategies is the difficulty in rapidly selecting clonal populations of biallelically edited cells.
Sameer Singh +3 more
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Medicina, 2022 Arboviruses have been reported over the years as constant threats to blood transfusion recipients, given the high occurrence of asymptomatic cases and the fact that the presence of viremia precedes the onset of symptoms, making it possible that infected ...
Leticia Martins Lamarão +10 more
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Serpentine and Vermiform Are Produced Autonomously to Fulfill Their Function in Drosophila Wings
Insects, 2023 Group I chitin deacetylases (CDAs), CDA1 and CDA2, play an essential role in cuticle formation and molting in the process of insect wing development. A recent report showed that trachea are able to take up a secreted CDA1 (serpentine, serp) produced in ...
Xubo Zhang +6 more
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Specificity Determination in Saccharomyces cerevisiae Killer Virus Systems
Microorganisms, 2021 Saccharomyces yeasts are widely distributed in the environment and microbiota of higher organisms. The killer phenotype of yeast, encoded by double-stranded RNA (dsRNA) virus systems, is a valuable trait for host survival. The mutual relationship between
Lina Aitmanaitė +4 more
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Clinical Microbiology Reviews, 1995 The use of nucleic acid-based vaccines is a novel approach to immunization that elicits immune responses similar to those induced by live, attenuated vaccines. Administration of nucleic acid vaccines results in the endogenous generation of viral proteins with native conformation, glycosylation profiles, and other posttranslational modifications that ...
F R, Vogel, N, Sarver
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Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA
Small Science, 2023 Ionizable lipids with branched tails have been used in lipid nanoparticles (LNPs)‐based messenger RNA (mRNA) therapeutics like COVID‐19 vaccines. However, due to the limited commercial availability of branched ingredients, a systematic analysis of how ...
Kazuki Hashiba +9 more
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Non-canonical DNA structures: Diversity and disease association
Frontiers in Genetics, 2022 A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA.
Aparna Bansal +4 more
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Current Opinion in Structural Biology, 2012 Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and ...
Sim, A, Minary, P, Levitt, M
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RNA ligase ribozymes with a small catalytic core
Scientific Reports, 2023 Catalytic RNAs, or ribozymes, catalyze diverse chemical reactions that could have sustained primordial life in the hypothetical RNA world. Many natural ribozymes and laboratory evolved ribozymes exhibit efficient catalysis mediated by elaborate catalytic
Yoko Nomura, Yohei Yokobayashi
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Nature Communications, 2022 Neutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput ...
Rachapun Rotrattanadumrong +1 more
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