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Nucleic acid reactivity and conformation I. Deamination of cytosine by nitrous acid
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972Abstract The rate of deamination of cytosine to uracil by nitrous acid was measured under several sets of conditions for the following compounds: cytidine, cytidine 5′-phosphate, poly(cytidylic acid) (in both single-stranded and half-protonated double helix forms), and the poly(I) · poly(C) complex. The relative reactivity of nucleoside : nucleotide :
Robert Shapiro, Hisao Yamaguchi
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Optical activity and the conformation of polynucleotide models of nucleic acids
Journal of Molecular Biology, 1965The interaction between polymers of adenylic and uridylic acids has been investigated using homopolyadenylate and homopolyuridylate, and copolymers containing various ratios of AMP and UMP randomly distributed. The measurements of circular dichroism in the region of 230 to 320 m μ indicate that the formation of the two-stranded poly (A + U)† helical ...
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Determination of the Conformation of Nucleic Acids by Electronic CD
1996The natural and synthetic nucleic acids are polymers of nucleotides that in turn are made up of an aromatic base, a sugar, and a phosphate group. The bases are the chromophores that absorb ultraviolet light to undergo electronic transitions, which begin at 300 nm and continue into the vacuum UV region.
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Nucleic acid conformation: crystal structure of a naturally occurring dinucleoside phosphate (UpA).
Nature: New biology, 1971N. Seeman+3 more
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Conformational penalties: New insights into nucleic acid recognition
Current Opinion in Structural BiologyThe energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuring conformational penalties and determining their contribution to the recognition, folding, and ...
Ainan, Geng+2 more
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Structure and Conformation of Nucleic Acids and Protein-Nucleic Acid Interactions [PDF]
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