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[Purine nucleoside phosphorylase (PNP)].
Nihon rinsho. Japanese journal of clinical medicine, 1997PNP, encoded by 6 exons on human chromosome 14q13, is a homotrimetic enzyme of approximately 96 k dalton. This enzyme reversibly catalyzes the phosphorolysis of purine nucleoside to their respective purine bases and the corresponding pentose-1-phosphate.
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Chapter 3. Purine Nucleoside Phosphorylase
2007Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine ribonucleosides and 2′-deoxypurine ribonucleosides to the free base, and ribose 1-phosphate or 2′-deoxyribose 1-phosphate, respectively.1–3 PNPs are found in most prokaryotic and eukaryotic organisms where the en...
Yang Zhang, Steven E. Ealick
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Use of Nucleoside Phosphorylases for the Preparation of Purine and Pyrimidine 2′-Deoxynucleosides
, 2018M. Drenichev +3 more
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Purine nucleoside phosphorylase deficiency.
Immunodeficiency reviews, 1991Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disease accounting for approximately 4% of patients with severe combined immunodeficiency. Thirty-three patients have been reported. PNP-deficient patients suffer from recurrent infections, usually beginning in the first year of life. Two thirds of patients have evidence of neurologic
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Synthesis of 2,6-Dihalogenated Purine Nucleosides by Thermostable Nucleoside Phosphorylases
, 2015Xinrui Zhou +5 more
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Unique substrate specificity of purine nucleoside phosphorylases from Thermus thermophilus
Extremophiles, 2013F. Tomoike, S. Kuramitsu, R. Masui
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