Results 331 to 340 of about 193,772 (411)

Reverse transcriptase inhibitors in Aicardi–Goutières syndrome: A crossover clinical trial

Developmental Medicine &Child Neurology, Volume 67, Issue 6, Page 750-757, June 2025.
Viral nucleic acid recognition induces a physiological type I interferon mediated innate immune response. In some cases of Aicardi‐Goutières syndrome, this same response is proposed to be triggered by self‐derived nucleic acid generated through reverse transcription. Here, reverse transcriptase inhibitors were assessed in such cases.
Yanick J. Crow, Tracy A. Briggs, Despina Eleftheriou, Amitav Parida, Claire Battison, Annabel Giddings, Titouan Kennel, Richard A. Parker, AGS‐RTIs Study Group, Aimee Donald, Paddy Mcmaster, Jay Shetty, Katherine Jack, Alan J Quigley, Alice Burleigh, Felice D’Arco, Cheryl Hemingway, Ying Hong, Elena Moraitis, Fiona Price‐Kuehne, Annapurna Sudarsanam, Evangeline Wassmer, Katie Livingstone, Fraser JH Sutherland, Marie‐Thérèse El‐Daher, John Norrie, Hannah Ensor, Alison F Munro, Lee Murphy, Alan Maclean, Katy R Reid, Deborah Forbes, Vincent Bondet, Darragh Duffy, David PJ Hunt, Gillian I Rice   +35 more
wiley   +1 more source

Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation. [PDF]

RSC Adv
Hedger AK, Findell J, Barak DS, Schiffer CA, Watts JK, Ali A.   +5 more
europepmc   +1 more source

Phase I study of pomalidomide in relapsed or refractory Waldenström macroglobulinaemia

British Journal of Haematology, EarlyView.
Karan L. Chohan, Donna M. Weber, Lei Feng, L. Michael Wang, Sattva S. Neelapu, Jasper Olsem, Ralph J. Johnson, Claudia Morales de Partovi, Robert Z. Orlowski, Sheeba K. Thomas   +9 more
wiley   +1 more source

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman, Alexandra Emerson, Peter M. Wilson, Karl A. Mulligan, Robert D. Ladner, Melissa J. LaBonte   +5 more
wiley   +1 more source

"Multi-layer" encryption of medical data in DNA for highly-secure storage. [PDF]

Mater Today Bio
Xu J, Wang Y, Chen X, Wang L, Zhou H, Mei H, Chen S, Huang X.   +7 more
europepmc   +1 more source

Production of Value-Added Arabinofuranosyl Nucleotide Analogues from Nucleoside by an In Vitro Enzymatic Synthetic Biosystem. [PDF]

Biomolecules
Liu Y, Zhang X, Yang E, Liu X, Su W, Wang Z, Wang H.   +6 more
europepmc   +1 more source

Site-Selective Modification and Labeling of Native RNA. [PDF]

Chemistry
Kha TK, Zhao Y, Zhu RY.
europepmc   +1 more source

NAIL-MS reveals tRNA and rRNA hypomodification as a consequence of 5-fluorouracil treatment. [PDF]

Nucleic Acids Res
Berg M, Li C, Kaiser S.
europepmc   +1 more source

Application of Mass Spectrometry for Analysis of Nucleobases, Nucleosides and Nucleotides in Tea and Selected Herbs: A Critical Review of the Mass Spectrometric Data. [PDF]

Foods
Frańska M, Frański R.
europepmc   +1 more source

Unmasking the halide effect in diastereoselective Grignard reactions applied to C4´ modified nucleoside synthesis. [PDF]

Nat Commun
Muir G, Caballero-García G, Muilu T, Nodwell M, Park Y, Huxley C, Kaghad A, Silverman SM, Campeau LC, Barroso-Flores J, Britton R.   +10 more
europepmc   +1 more source