Results 221 to 230 of about 262,017 (266)

Nucleotide Analog Interference Mapping

2009
Nucleotide analog interference mapping (NAIM) is a powerful chemogenetic technique that rapidly identifies chemical groups essential for RNA function. Using a series of phosphorothioate-tagged nucleotide analogs, each carrying different modifications of nucleobase or backbone functionalities, it is possible to simultaneously, yet individually, assess ...
Ian T, Suydam, Scott A, Strobel
openaire   +2 more sources

Single-Nucleotide Polymorphism Mapping

2006
Single-nucleotide polymorphism (SNP) mapping is the easiest and most reliable way to map genes in Caenorhabditis elegans. SNPs are extremely dense and usually have no associated phenotype, making them ideal markers for mapping. SNP mapping has three steps.
M Wayne, Davis, Marc, Hammarlund
openaire   +2 more sources

Nucleotide Analog Interference Mapping

Cold Spring Harbor Protocols, 2015
Methods collectively known as modification interference are exceptionally powerful approaches used to identify functionally important chemical groups in the phosphodiester backbone or nucleobases of an RNA. In a modification interference assay, end-labeled RNAs that have been modified at different positions are allowed to participate in a reaction of ...
openaire   +2 more sources

Single Nucleotide Polymorphism Mapping Array Assay

2007
Single nucleotide polymorphisms (SNPs) are the most frequent form of DNA variation present in the human genome, and millions of SNPs have been identified http://www.ncbi.nlm.nih.gov/SNP/). Because of their abundance, even spacing, and stability across the genome, SNPs have significant advantages over other genetic markers (such as restriction fragment ...
Xiaofeng, Zhou, David T W, Wong
openaire   +2 more sources

Online Nucleotide Mapping of mRNAs

Analytical Chemistry
Messenger RNA (mRNA) can be sequenced via indirect approaches such as Sanger sequencing and next generation sequencing (NGS), or direct approaches like bottom-up mass spectrometry (MS). Direct sequencing allows the confirmation of RNA modifications.
Alexandre Goyon, Brandon Scott, Peter Yehl, Kelly Zhang   +3 more
openaire   +2 more sources

Nucleotide Excision Repair Map of Drosophila at Single Nucleotide Resolution

2022
Drosophila Melanogaster is an extensively used model system in the scientific community. It has been traditionally used to study ionizing radiation and chemical induced mutagenesis, double strand break repair and recombination. Despite these extensive work in these research areas, there are only limited number of studies on nucleotide excision repair ...
openaire   +1 more source

Patterns of nucleotide diversity and association mapping

2011
International ...
González-Martínez, Santiago C., Dillon, S., Garnier‐géré, Pauline, Gil, M.R., Grivet, D., Heuertz, Myriam, Jaramillo-Correa, J.P., Lascoux, M., Neale, D.B., Savolainen, O.   +9 more
  +7 more sources

Single nucleotide polymorphism map of five long-QT genes

Journal of Molecular Medicine, 2004
We screened a white population for single nucleotide polymorphisms (SNPs) in five long QT syndrome genes, namely, KCNQ1 (LQT1), HERG (LQT2), SCN5A (LQT3), KCNE1 (LQT5), and KCNE2 (LQT6). We found 35 SNPs, 10 of which have not been previously described. Ten SNPs were in KCNE1, six in HERG, eight in KCNQ1, four in KCNE2, and seven in SCN5A.
Atakan, Aydin, Sylvia, Bähring, Stefan, Dahm, Ulf P, Guenther, Regina, Uhlmann, Andreas, Busjahn, Friedrich C, Luft   +6 more
openaire   +2 more sources

The use of single-nucleotide polymorphism maps in pharmacogenomics

Nature Biotechnology, 2000
Single-nucleotide polymorphisms (SNPs), common variations among the DNA of individuals, are being uncovered and assembled into large SNP databases that promise to enable the dissection of the genetic basis of disease and drug response (i.e., pharmacogenomics).
J J, McCarthy, R, Hilfiker
openaire   +2 more sources

Single nucleotide polymorphisms and fine mapping QTL in chickens

HEREDITAS, 2007
As an important economically animal and a model animal, a great of progress of SNP diversity and QTL mapping in chickens have been made in recent years. The present paper not only summarized these achievements but also commanded an extensive view about the fine mapping of QTL by the use of SNP marker.
You-Sheng, Rao, Xi-Quan, Zhang
openaire   +2 more sources