Results 141 to 150 of about 2,090,052 (356)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Subcellular Localization Screening of Colletotrichum higginsianum Effector Candidates Identifies Fungal Proteins Targeted to Plant Peroxisomes, Golgi Bodies, and Microtubules

Frontiers in Plant Science, 2018
The genome of the hemibiotrophic anthracnose fungus, Colletotrichum higginsianum, encodes a large inventory of putative secreted effector proteins that are sequentially expressed at different stages of plant infection, namely appressorium-mediated ...
Guillaume P. Robin, Jochen Kleemann, Ulla Neumann, Lisa Cabre, Jean-Félix Dallery, Nicolas Lapalu, Richard J. O’Connell   +6 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Event Anisotropy in High Energy Nucleus-Nucleus Collisions

, 1998
The predictions of event anisotropy parameters from transport model RQMD are compared with the recent experimental measurements for 158$A$ GeV Pb+Pb collisions.
A. Poskanzer, B. Blättel, D. H. Rischke, H. Appelshauser, H. H. Gutbrod, H. Liu, H. Sorge, H. Sorge, H. Sorge, J. Barrette, J.-Y. Ollitrault, L. P. Csernai, M. Gyulassy, M. Partlan, N. Xu, P. Crochet, P. Danielewicz, P. Danielewicz, S. Panitkin, S. Voloshin, S. Voloshin, S. Voloshin, U. A. Wiedemann, W. Reisdorf   +23 more
core   +2 more sources

Dynamic Virus-Dependent Subnuclear Localization of the Capsid Protein from a Geminivirus

Frontiers in Plant Science, 2017
Viruses are intracellular parasites with a nucleic acid genome and a proteinaceous capsid. Viral capsids are formed of at least one virus-encoded capsid protein (CP), which is often multifunctional, playing additional non-structural roles during the ...
Liping Wang, Liping Wang, Huang Tan, Huang Tan, Mengshi Wu, Mengshi Wu, Tamara Jimenez-Gongora, Tamara Jimenez-Gongora, Li Tan, Rosa Lozano-Duran   +9 more
doaj   +1 more source

The Aspherical Nucleus Theory Applied to the Principal Series of Helium [PDF]

, 1922
Ludwik Silberstein
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

New features in DPMJET version II.5 [PDF]

arXiv, 1999
DPMJET is a Monte Carlo model for sampling of hadron-hadron, hadron-nucleus, nucleus-nucleus and neutrino-nucleus interactions at accelerator and Cosmic Ray energies according to the two-component Dual Parton Model. Here we describe new features in version DPMJET-II.5: Implementation of new DPM diagrams for an improved description of baryon stopping in
arxiv  

The Nucleus of Adipose Tissue [PDF]

, 1871
Lionel S. Beale
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source