Results 171 to 180 of about 1,379,939 (300)
Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation
Étienne Audet-Walsh +2 more
doaj +1 more source
Hypothalamic Neurochemical and Microglial Suppression in Long-Standing Human Hibernation-Like Syndrome. [PDF]
Jiang W +4 more
europepmc +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Genome-Wide Identification and Analysis of the Perennial Ryegrass (<i>Lolium perenne</i> L.) WRKY Family Associated with Heat Stress. [PDF]
Chen W, Song N, Zhang J, Xu B, Chi Y.
europepmc +1 more source
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Whole-brain mapping of spinal-projecting neurons in larval zebrafish. [PDF]
Carbo-Tano M +6 more
europepmc +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
Exercise therapy for chronic pain: an updated perspective on mesocorticolimbic system function. [PDF]
Senba E +6 more
europepmc +1 more source

