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Composite Hydrogels for the Replacement of the Nucleus Pulposus [PDF]
, 2009 The intervertebral disc (IVD), which provides flexibility to the spine and facilitates damping and motion, is composed of two distinct structures: the annulus fibrosus (AF) and the nucleus pulposus (NP). The AF, which is fibrous and elastic, confines the NP, a gel-like material, containing 65 to 90% of water.
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Replacing the nucleus pulposus of the intervertebral disc
Clinical Biomechanics, 2001To determine whether replacement of the nucleus with a synthetic material would prevent the effects of nucleus removal.Laboratory experiments on excised tissues and a finite element model.Removal of the nucleus from the intervertebral disc causes the inner margins of the annulus to bulge inwards, instead of outwards, during compression.
Janet Elizabeth Reid +2 more
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Thoracic Herniated Nucleus Pulposus
2019The indications for minimally invasive spine surgery (MISS) for the treatment of thoracic disc disease have evolved and expanded over the past decade with the development of newer technologies and refined techniques. Symptomatic thoracic disc herniations are uncommon, which provides a paucity of literature exploring common surgical treatment options ...
Krystin A. Hidden +2 more
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Stem cell regeneration of the nucleus pulposus
The Spine Journal, 2004Low back pain due to disc degeneration is one of the largest health problems faced in this nation when judged by lost work time and direct as well as indirect costs. Many experimental methods are being explored to treat or to reverse the effect of disc degeneration. This article reviews the strategy of a tissue engineering approach to disc regeneration.
Alexander R. Vaccaro +3 more
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Nucleus pulposus replacement: an emerging technology
The Spine Journal, 2005Debilitating low back pain as a result of symptomatic lumbar disc degeneration places a significant burden on an industrial society. Traditionally surgical treatment involving fusion of the anterior and posterior spinal elements has resulted in unpredictable and frequently irreproducible results, especially with regard to return to work rates.
David W. Wimberley +4 more
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Banded Structures in Human Nucleus Pulposus
Clinical Orthopaedics and Related Research, 1979We studied 20 intervertebral disks from cervical, thoracic, and lumbar levels from patients 12 hours to 55-years-old by electronmicroscopy. Tissue was obtained at operation from 10 patients with scoliosis and 6 with herniation of the intervertebral disk. Four intervertebral disks were removed at autopsies performed within 4 hours of death.
Joseph A. Buckwalter +2 more
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Lumbar Herniated Nucleus Pulposus
2019This chapter will discuss the pathophysiology, exam, diagnosis, and management of lumbar disc herniation (LDH). In brief, LDH is a common pathology that affects a significant percentage of the population. The natural history of LDH is favorable, and excellent results have been obtained following conservative management.
Philip K. Louie, Gregory D. Lopez
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Thoracic Herniated Nucleus Pulposus
2014Minimally invasive spine surgery in the treatment of thoracic disc disease has benefited from an explosion in technology over the past decade. However, to be valuable, the minimally invasive surgical approach in the treatment of thoracic disc disease must achieve the goal of equal outcomes when compared to open surgical procedures while at the same ...
Jong G. Park +3 more
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Lumbar Herniated Nucleus Pulposus
2014This chapter will discuss the pathophysiology, exam, diagnosis, and management of lumbar disc herniation (LDH). In brief, LDH is a common pathology that will affect a significant portion of the population. The natural history of LDH is favorable, and excellent results have been obtained with conservative management.
Gurvinder S. Deol, Daniel L. Cavanaugh
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Enzyme Dissolution of the Nucleus Pulposus in Humans
JAMA, 1964CHYMOPAPAIN, by direct injection into the intervertebral disc, will cause dissolution of the nucleus pulposus in rabbits without apparent effect on the surrounding tissues, such as ligaments, bone, nerve roots, and dura mater. 1 This technique was therefore applied to 22 dogs with paralysis of the hind legs believed to be due to herniation of ...
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