Results 51 to 60 of about 2,583,298 (291)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

STRING QUANTIZATION IN CURVED SPACETIMES: NULL STRING APPROACH [PDF]

Modern Physics Letters A, 1995
We study quantum strings in strong gravitational fields. The relevant small parameter is [Formula: see text] where Rc is the curvature of the spacetime and T0 is the string tension. Within our systematic expansion we obtain to zeroth-order the null string (string with zero tension), while the first-order correction incorporates the string dynamics. We
de Vega, H. J., Giannakis, I., Nicolaidis, A.   +2 more
openaire   +3 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

On pseudo null and null cartan darboux helices in minkowski 3-space

Kuwait Journal of Science, 2016
In this paper, we introduce the notion of pseudo null and null Cartan Darboux helicesin Minkowski 3-space. We characterize the Darboux vectors of the pseudo null andthe null Cartan curves in terms of the Darboux helices and the rectifying curves.
Ufuk Öztürk, Emilija Nešović
doaj  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Integrable system of null curve and Betchov-Da Rios equation

Demonstratio Mathematica
This study focuses on the time evolution of a null curve using a new frame and a new transformation in Minkowski 3-space. Accordingly, Landau–Lifshitz and coupled Boussinesq-like equations for the null curve are provided in terms of the new ...
Yoon Dae Won
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

The Casual Characteristics of Offset Curves of a Non-Null Curve and Fibonacci Sequence

, 2023
Fibonacci sequence is a very interesting sequence. In this paper, first the casual characteristics of the involute curve, and Mannheim partner of a non-null curve are examined.
Suleyman SENYURT, Seyda KILICOGLU
core   +1 more source

On Backlund transformation and motion of null Cartan curves [PDF]

, 2022
The main scope of this paper is to examine null Cartan curves especially the ones with constant torsion. In accordance with this scope, the position vector of a null Cartan curve is stated by a linear combination of the vector fields of its pseudo ...
Yavuz, Ayse, Erdogdu, Melek
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source