Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth +7 more
wiley +1 more source
Distributed Network Tomography Applied to Stochastic Delay Profile Estimation [PDF]
In this paper is shown, how delay properties of the edges of a network with stochastic properties can be estimated cooperatively by individual nodes that retain the delay profiles of the entire network. The proposed algorithm adopts null-space projection-
J. Kolar, J. Sykora, U. Spagnolini
doaj
The Key Indicators of the Normality of Distribution
Statistics plays an important role in describing the results of various research. The basic role of statistical reasoning is to enable generalizations valid for the entire population to be made on the basis of certain quantitative characteristics of the ...
Zoran Č. Vidović +1 more
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Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge +4 more
wiley +1 more source
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Identification of Conserved Moieties in Metabolic Networks by Graph Theoretical Analysis of Atom Transition Networks. [PDF]
Conserved moieties are groups of atoms that remain intact in all reactions of a metabolic network. Identification of conserved moieties gives insight into the structure and function of metabolic networks and facilitates metabolic modelling.
Hulda S Haraldsdóttir +1 more
doaj +1 more source
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Graph‐based spectrum sensing algorithm via nonlinear function regulation
To solve the difficulties in threshold selection and poor performance under low signal‐to‐noise ratio (SNR) conditions in existing spectrum sensing algorithms, a graph‐based spectrum sensing algorithm using nonlinear function regulation was proposed. The
Shanshan Wu, Guobing Hu
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Chromatic transitions in the emergence of syntax networks [PDF]
The emergence of syntax during childhood is a remarkable example of how complex correlations unfold in nonlinear ways through development. In particular, rapid transitions seem to occur as children reach the age of two, which seems to separate a two-word,
Bernat Corominas-Murtra +3 more
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Beyond Order: Perspectives on Leveraging Machine Learning for Disordered Materials
This article explores how machine learning (ML) revolutionizes the study and design of disordered materials by uncovering hidden patterns, predicting properties, and optimizing multiscale structures. It highlights key advancements, including generative models, graph neural networks, and hybrid ML‐physics methods, addressing challenges like data ...
Hamidreza Yazdani Sarvestani +4 more
wiley +1 more source

