Results 81 to 90 of about 1,519,388 (324)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Scalable Null Model for Directed Graphs Matching All Degree Distributions: In, Out, and Reciprocal [PDF]

, 2013
Degree distributions are arguably the most important property of real world networks. The classic edge configuration model or Chung-Lu model can generate an undirected graph with any desired degree distribution.
Durak, Nurcan, Kolda, Tamara G., Pinar, Ali, Seshadhri, C.   +3 more
core   +1 more source

Comparison among Hamiltonian light-front formalisms at q+ = 0 and q+ <> 0: space-like elastic form factors of pseudoscalar and vector mesons [PDF]

, 2002
The electromagnetic elastic form factors of pseudoscalar and vector mesons are analyzed for space-like momentum transfers in terms of relativistic quark models based on the Hamiltonian light-front formalism elaborated in different reference frames (q+ 0 ...
B.D. Keister, D. Melikhov, D. Melikhov, D. Melikhov, D. Melikhov, D. Politzer, D.E. Groom, F. Cardarelli, F. Cardarelli, F. Cardarelli, F. Coester, F. Lev, G.P. Lepage, H. Georgi, H.J. Melosh, I.L. Grach, I.L. Grach, J. Carbonell, K. Melnikov, L.L. Frankfurt, M. Sawicki, M.B. Voloshin, N. Isgur, N. Isgur, N.B. Demchuk, P.L. Chung, R. Wagenbrunn, S. Godfrey, S. Simula, S.R. Amendolia, S.R. Amendolia, Silvano Simula, T. Frederico, V.A. Karmanov, V.A. Karmanov, V.A. Karmanov, W. Jaus, W.H. Klink   +37 more
core   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

An algebraic analysis of the graph modularity

, 2014
One of the most relevant tasks in network analysis is the detection of community structures, or clustering. Most popular techniques for community detection are based on the maximization of a quality function called modularity, which in turn is based upon
Fasino, Dario, Tudisco, Francesco
core   +1 more source

Configuring Random Graph Models with Fixed Degree Sequences [PDF]

SIAM Review, 2016
Random graph null models have found widespread application in diverse research communities analyzing network datasets, including social, information, and economic networks, as well as food webs, protein-protein interactions, and neuronal networks.
B. Fosdick, D. Larremore, Joel Nishimura, J. Ugander   +3 more
semanticscholar   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Assessing portfolio diversification via two-sample graph kernel inference. A case study on the influence of ESG screening.

PLoS ONE
In this work we seek to enhance the frameworks practitioners in asset management and wealth management may adopt to asses how different screening rules may influence the diversification benefits of portfolios.
Ragnar L Gudmundarson, Gareth W Peters
doaj   +1 more source

Testing for high-dimensional geometry in random graphs

, 2015
We study the problem of detecting the presence of an underlying high-dimensional geometric structure in a random graph. Under the null hypothesis, the observed graph is a realization of an Erd\H{o}s-R\'enyi random graph $G(n,p)$.
Bubeck, Sébastien, Ding, Jian, Eldan, Ronen, Rácz, Miklós   +3 more
core   +1 more source

Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg, Brad Rovin, Brad C. Astor, Tripti Singh, Fauzia Hollnagel, Megan Kuik, Lexie Kolton, Callie Saric, S. Sam Lim, Christie M. Bartels   +9 more
wiley   +1 more source