Results 31 to 40 of about 365,966 (282)
Frontiers in Neuroscience, 2018 Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure.
Tom A. de Graaf +3 more
doaj +1 more source
THE ROLE OF EMOTIONAL CATHARSIS PROGRAM IN DECREASING RELIGIOUS FANATICISM
مجلة الآداب, 2019 The present study examines the credibility of the null hypothesis which illustrates that (there are no significant differences between the group under experiment and the group under control concerning fanaticism). It examines as well religious fanaticism
Ahmed Latif Jassim +1 more
doaj +1 more source
Bleeding, Thrombosis and Vascular Biology, 2022 Scientific literature is overflowing of significance testing and p-values.
Augusto Di Castelnuovo +1 more
doaj +1 more source
Statistical hypothesis testing: general approach in medical research
Сеченовский вестник, 2021 Statistical hypothesis testing is one of the key steps in modern medical research. Initially, scientists formulate a research hypothesis based on which the statistical hypothesis is then developed and statistically tested.
A. Yu. Suvorov +6 more
doaj +1 more source
Disease Models & Mechanisms, 2014 Science is often romanticised as a flawless system of knowledge building, where scientists work together to systematically find answers. In reality, this is not always the case. Dissemination of results are straightforward when the findings are positive,
Natalie Matosin +4 more
doaj +1 more source
Bayes factors for superiority, non-inferiority, and equivalence designs
BMC Medical Research Methodology, 2019 Background In clinical trials, study designs may focus on assessment of superiority, equivalence, or non-inferiority, of a new medicine or treatment as compared to a control.
Don van Ravenzwaaij +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source