A null model for microbial diversification [PDF]
Proceedings of the National Academy of Sciences, 2017 SignificanceWhen evolutionary histories of closely related microorganisms are reconstructed, the lineages often cluster into visibly recognizable groups. However, we do not know if these clusters represent fundamental units of bacterial diversity, such as “species,” nor do we know the nature of evolutionary and ecological forces that are responsible ...
Timothy J. Straub, Olga Zhaxybayeva
semanticscholar +4 more sources
Null-model-based network comparison reveals core associations [PDF]
ISME Commun, 2021 Microbial network construction and analysis is an important tool in microbial ecology. Such networks are often constructed from statistically inferred associations and may not represent ecological interactions.
Lisa Röttjers +3 more
semanticscholar +2 more sources
The consequences of null model selection for predicting mortality from multiple stressors [PDF]
Proc Biol Sci, 2021 Many ecological systems are now exposed to multiple stressors, and ecosystem management increasingly requires consideration of the joint effects of multiple stressors on focal populations, communities and ecosystems.
C. Dey, M. Koops
semanticscholar +2 more sources
Toward an Evolutionarily Appropriate Null Model: Jointly Inferring Demography and Purifying Selection [PDF]
Genetics, 2020 The relative evolutionary roles of adaptive and non-adaptive processes remain a central question in population genetics. Resolution of this debate has been difficult as an appropriate null model incorporating...
Parul Johri +2 more
semanticscholar +4 more sources
A null model of the mouse whole-neocortex micro-connectome [PDF]
Nat Commun, 2019 In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale
Michael W. Reimann +5 more
semanticscholar +2 more sources
Constructing networks by filtering correlation matrices: a null model approach [PDF]
Proc Math Phys Eng Sci, 2019 Network analysis has been applied to various correlation matrix data. Thresholding on the value of the pairwise correlation is probably the most straightforward and common method to create a network from a correlation matrix.
Sadamori Kojaku, N. Masuda
semanticscholar +2 more sources
Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome † [PDF]
Int J Mol Sci, 2018 Decreased corneal innervation is frequent in patients with Sjögren Syndrome (SS). To investigate the density and morphology of the intraepithelial corneal nerves (ICNs), corneal sensitivity, epithelial cell proliferation, and changes in mRNA expression ...
M. Stepp +5 more
semanticscholar +2 more sources
Null Model and Community Structure in Multiplex Networks [PDF]
Sci Rep, 2018 The multiple relationships among objects in complex systems can be described well by multiplex networks, which contain rich information of the connections between objects. The null model of networks, which can be used to quantify the specific nature of a
Xuemeng Zhai +7 more
semanticscholar +2 more sources
Dissecting the null model for biological invasions: A meta-analysis of the propagule pressure effect [PDF]
PLoS Biol, 2018 A consistent determinant of the establishment success of alien species appears to be the number of individuals that are introduced to found a population (propagule pressure), yet variation in the form of this relationship has been largely unexplored ...
P. Cassey +4 more
semanticscholar +2 more sources
BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism [PDF]
Sci Rep, 2017 Clinical efficacy regularly requires the combination of drugs. For an early estimation of the clinical value of (potentially many) combinations of pharmacologic compounds during discovery, the observed combination effect is typically compared to that ...
K. Van der Borght +7 more
semanticscholar +2 more sources