Results 31 to 40 of about 4,167,707 (293)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
On the rapid use of verb-control information in sentence processing
Frontiers in PsychologyA central topic in psycholinguistics is the study of how and when the parser assigns an antecedent to referentially-dependent elements. One such referentially-dependent element is the null subject of non-finite clauses.
Josep Demestre
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
La référence impersonnelle humaine en langue des signes française
TIPA. Travaux interdisciplinaires sur la parole et le langage, 2018 The study presented in this paper is a first systematic approach to the expression of the impersonal human reference in French sign language (LSF). It extends and deepens a prior study carried out by the authors on the basis of a large scale discourse ...
Brigitte Garcia +3 more
doaj +1 more source
Discours, 2020 The present study investigates subject expression in two generations of Portuguese migrants living in Hamburg, Germany. Based on a corpus of oral speech, we aim to assess whether second generation heritage speakers (HSs) differ from first generation ...
Cristina Flores, Esther Rinke
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
IsoglossThis paper revisits the status of subject clitics in Spoken French by studying subject doubling as a sociolinguistic variable. In the literature, two influential analyses have been proposed to account for French subject doubling.
Yiming Liang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Null/overt subject alternations in L2 Spanish and L2 Greek
Glossa, 2020 This study aims at exploring the omission/expression of subjects in L2 Spanish and L2 Greek. The distribution of subjects is examined in the context of the Interface Hypothesis (IH), which locates the difficulty of acquisition at the syntax-pragmatics ...
Anna Gavarró, Panagiota Margaza
doaj +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source