Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Weight Loss Outcomes of Routine Dietetic Treatment in Primary Care. [PDF]
van de Riet A +5 more
europepmc +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Access to Essential Services: A Critical Factor for Predicting Recovery and Quantifying Resilience. [PDF]
Swanson T +3 more
europepmc +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Metformin Attenuates Behavioral Deficits and Oxidative Stress in a Preclinical Model of Autism. [PDF]
Freitas MC +9 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A study of unsteady MHD free convection flow through a porous vertical flat plate immersed in a porous medium in presence of magnetic field with radiation has been analyzed.
Ec Eckert Number +2 more
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Herbicide and pesticide effects on the earthworm species Eisenia foetida (Savigny, 1826) (Oligochaeta, Lumbricidae) [PDF]
Stojanović Mirjana +2 more
doaj +1 more source
Number-line estimation training in preschoolers supports early mathematical development and is associated with a stronger approximate-to-symbolic numerical pathway. [PDF]
Morell-Ruiz M +5 more
europepmc +1 more source

