Results 41 to 50 of about 58,715 (251)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regional Differences in Visitor Numbers and Overnight Stays in Slovakia in the Context of the COVID-19 Pandemic

Sustainability
This study presents a comprehensive regional analysis of the COVID-19 pandemic’s impact on tourism in Slovakia during 2018–2024, employing rigorous statistical methods to quantify sectoral transformations. Based on extensive data on visitor arrivals, revenues, and accommodation facility utilisation across eight NUTS III regions, the analysis identifies
Maksym Mykhei, Kristína Pramuková, Ľubomír Štrba, Marcela Taušová, Nikola Kottferová   +4 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Uneven domestic tourism demand in times of pandemic

, 2023
This study investigates the short-run impact of the COVID-19 pandemic on the number of domestic overnight stays at the regional level in the summer season 2020.
Lin, Xiang, Eva Hagsten, Hagsten, Eva, Hagsten, Eva,, Falk, Martin, Xiang Lin, Martin Falk, Falk, Martin,, Lin, Xiang,   +8 more
core   +1 more source

Tourism and travel at Divčibare [PDF]

Zbornik Radova: Geografski Fakultet Univerziteta u Beogradu, 2023
The nature of Serbia is a first-class tourist value, which is based, among other things, on a large number of mountains, which have different types and times of formation, tectonic structure, geological composition, extent, height and rise of the ...
Stanković Stevan M.
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multidimensional scaling analysis in positioning the provinces in Turkey according to the number of tourist arrivals and overnight stays

UTK 2021 Turizm Özel Sayısı, 2021
Nowadays in the tourism sector; Comparing, ranking or grouping units such as countries, country groups, regions, or provinces has a guiding quality to provide competitive advantages and achieve economic goals. In the realization of these studies, multivariate statistical techniques can enable many variables to be evaluated together.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

THE IMPACT OF COVID-19 PANDEMIC ON ROMANIA'S TOURIST FLOWS IN THE YEAR 2020 [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2021
The paper aimed to analyze in what measure the Covid-19 pandemic has influenced tourist flows in Romania's tourism in the year 2020 comparatively with the year 2019 and the 2020 forecast.
Agatha POPESCU
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source