Results 81 to 90 of about 107,694 (265)

Variability of the data indicating the fertility of different plum varieties

International Journal of Horticultural Science, 2003
Self-fertility and fertility at conditions of open pollination in plum varieties is strictly determined by genetic factors. However, rates of fruit set are highly variable according to growing sites as well as to seasons, which may result from a couple ...
Z. Szabó, J. Nyéki
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Smarandache Replicating Digital Function Numbers

, 2006
In 1987, Mike Keith introduced "repfigits" (replicating Fibonacci-like digits) [1]. In this paper two generalizations of repfigits are presented in which Smarandache type functions are applied to the digits of n. Some conjectures and unsolved questions are then proposed.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

How many 24-hour recalls or food records are required to estimate usual energy and nutrient intake?

Cadernos de Saúde Pública
For dietary intake assessments, one needs to know the minimum 24-hour recall or food record replications that are required to estimate usual energy and nutrient intake and to classify subjects correctly according to their nutrient intake.
Rosângela Alves Pereira, Marina Campos Araujo, Taís de Souza Lopes, Edna Massae Yokoo   +3 more
doaj   +2 more sources

Optimum plot size for experiments with the sunflower1

Revista Ciência Agronômica
The aim of this study was to determine a suitable plot size for field experiments with the sunflower. An experiment was carried out in a randomised complete block design with 14 sunflower cultivars and 10 replications.
Roberto Pequeno de Sousa, Paulo Sérgio Lima e Silva, Janilson Pinheiro de Assis, Paulo Igor Barbosa e Silva, Júlio César do Vale Silva   +4 more
doaj   +1 more source

An Optimal Sample Data Usage Strategy to Minimize Overfitting and Underfitting Effects in Regression Tree Models Based on Remotely-Sensed Data

Remote Sensing, 2016
Regression tree models have been widely used for remote sensing-based ecosystem mapping. Improper use of the sample data (model training and testing data) may cause overfitting and underfitting effects in the model.
Yingxin Gu, Bruce K. Wylie, Stephen P. Boyte, Joshua Picotte, Daniel M. Howard, Kelcy Smith, Kurtis J. Nelson   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source