Results 181 to 190 of about 170,968 (284)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Biogeographic history of the Late Pleistocene and Holocene European small hamsters (subfamily Cricetinae). [PDF]

Sci Rep
Bujalska B, Golubiński M, Popović D, Berto C, Conard NJ, Lemanik A, Luzi E, Marković Z, Nadachowski A, Popov V, Horáček I, Baca M.   +11 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genomic monitoring and tracking of mpox virus clade Ib in Burundi between july to september 2024. [PDF]

Commun Med (Lond)
Nzoyikorera N, Schuele L, Nieuwenhuijse DF, Nduwimana C, Ihorimbere T, Niyomwungere D, Cassidy H, Boter M, Nibogora C, Ndihokubwayo A, Niyomwungere A, Nizigiyimana D, Uwineza MN, Diawara I, Otani S, Aarestrup FM, Koopmans M, Nyandwi J, Oude Munnink BB.   +18 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Geographic and cross-species transmission of Mamastroviruses from multiple hosts. [PDF]

Anim Microbiome
Wang Y, Wu H, Liu X, Ma H, Li A, Li Y, Guo X.   +6 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Mitogenomic analyses uncover significant genetic differentiation between different geographic populations of <i>Acrossocheilus fasciatus</i>. [PDF]

Mitochondrial DNA B Resour
Yuan Y, Zhang H, Jiang S, Yang X, Chung-Davidson YW, Li W, Li J, Li F, Ren J.   +8 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Revisiting the relationships among howler monkeys through molecular phylogenetic analysis (Primates; Atelidae; Alouatta). [PDF]

Primates
da Silva DF, de Sousa RPC, Bessa-Silva A, Gomes GFE, Vallinoto M, Sampaio I.   +5 more
europepmc   +1 more source