Results 71 to 80 of about 170,968 (284)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Implementation of Mathematics through Problem-Based Learning Models Assisted by Numbers Media
Pena AndaMathematics is a basic science that has a role in shaping students' thinking patterns. In mathematics, students are equipped with various abilities to use logic, systematic, analytical, and critical thinking, as well as to use mathematics in problem ...
Miqwati, Hanafi
doaj +1 more source
The beast initiate: the lycanthropy of Heracles [PDF]
, 2019 The obscurantist Hellenistic poet Lycophron referenced the initiation of Heracles as a beast suckling the breast of the goddess Hera. This was the event that was the mythological origin of the Galaxy and of the lily flower that incarnated the same ...
Ruck, Carl
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Известия Южного федерального университета: Филологические науки, 2016 The article deals with the metaphor as an integral component of the ornamental prose. It is assumed that the paths based on the similarity of the compared concepts mean in a literary text the presence of not only common knowledge, but also the copyright ...
Lugovaya Nika Vyacheslavovna
doaj +1 more source
Eros and Pilgrimage in Chaucer’s and Shakespeare’s Poetry [PDF]
, 2013 The paper discusses erotic desire and the motif of going on pilgrimage in the opening of Geoffrey Chaucer’s General Prologue to The Canterbury Tales and in William Shakespeare’s sonnets.
Kowalik, Barbara
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Virology Journal, 2011 Background Hepatitis C virus (HCV) is an important human pathogen affecting around 3% of the human population. In Brazil, it is estimated that there are approximately 2 to 3 million HCV chronic carriers.
Pinho João RR +5 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source