Results 271 to 280 of about 6,028,955 (329)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Why do we differ in number sense? Evidence from a genetically sensitive investigation.
Intelligence, 2014 Tosto MG +11 more
europepmc +1 more source
Power Patterns: Extending Number Sense through Last Digit Investigations.
, 2016 John West
openalex +1 more source
Renegar's Condition Number, Sharpness and Compressed Sensing Performance
, 2015 Vincent Roulet +2 more
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The Journal of Special Education, 1999
We describe the concept of number sense, an analog as important to mathematics learning as phonemic awareness has been to the reading research field. Understanding the concept of number sense and relevant research from cognitive science can help the research community pull together fragmented pieces of earlier knowledge to yield a much richer, more ...
Russell Gersten, David Chard
openaire +1 more source
We describe the concept of number sense, an analog as important to mathematics learning as phonemic awareness has been to the reading research field. Understanding the concept of number sense and relevant research from cognitive science can help the research community pull together fragmented pieces of earlier knowledge to yield a much richer, more ...
Russell Gersten, David Chard
openaire +1 more source
2018
In this activity, students demonstrate their own innate number sense by playing an online game that asks them to estimate quantities that are flashed on screen for only milliseconds.
Fleming-Davies, Arietta, Wojdak, Jeremy
openaire +1 more source
In this activity, students demonstrate their own innate number sense by playing an online game that asks them to estimate quantities that are flashed on screen for only milliseconds.
Fleming-Davies, Arietta, Wojdak, Jeremy
openaire +1 more source
Proceedings of the 4th International Conference on Learning Innovation and Quality Education, 2020
Number sense is an ability that owned by individual to know and to understand of symbol of numbers, concepts of numbers and how to operate them. The right game and good management of children's emotional intelligence can develop the ability of number sense in children.
Monica Roito Ambarita +2 more
openaire +1 more source
Number sense is an ability that owned by individual to know and to understand of symbol of numbers, concepts of numbers and how to operate them. The right game and good management of children's emotional intelligence can develop the ability of number sense in children.
Monica Roito Ambarita +2 more
openaire +1 more source
Teaching Children Mathematics, 2010
Consider using a game-based assessment of number sense in young children, including those at risk because of socioeconomic level, disability, or the necessity of learning a second language.
Sally Moomaw +3 more
openaire +1 more source
Consider using a game-based assessment of number sense in young children, including those at risk because of socioeconomic level, disability, or the necessity of learning a second language.
Sally Moomaw +3 more
openaire +1 more source