Results 101 to 110 of about 949 (276)

The coalescence of grammatical gender and numeral classifiers in the general classifier wota in Nepali

open access: yes, 2018
While nominal classification has received considerable attention, relatively little is known about cross-linguistically rare complex systems. An example is provided by Nepali (Indo-European, Indic), which possesses both grammatical gender and numeral ...
Marcin Kilarski   +4 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The acquisition of numeral classifiers by Malay children

open access: yes, 2009
Numeral classifiers are typically used in counting or referring to objects. Numeral classifiers acquisition is of interest to researchers as researchers are able to examine how children learn to categorise and label objects in their environment using a ...
Salehuddin, Khazriyati
core  

Plant-based numeral classifiers in Tai Dam [PDF]

open access: yes, 2014
Inanimate entities are basically classified into different categories based on their physical forms. The geometric shapes themselves are drawn from naturally occurring forms. They refer to plants, in their component parts (Conklin 1981).
Burusphat, Somsonge
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

The pragmatics of Malay numeral classifiers: an investigation of modern Malay corpus

open access: yes, 2008
Anaphora and definiteness are most commonly expressed in Malay via the use of pronouns (e.g. “dia”, “mereka”) and the language’s kata penentu (i.e. “itu”, “ini”) respectively (Abdullah Hassan, 1993; Nik Safiah Karim, 1995).
Winskel, Heather, Salehuddin, Khazriyati
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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