Results 81 to 90 of about 3,518,834 (296)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Two optimized novel potential formulas and numerical algorithms for [Formula: see text] cobweb and fan resistor networks. [PDF]

Sci Rep, 2023
Zhao W, Zheng Y, Jiang X, Jiang Z.
europepmc   +1 more source

Numerical Zoom and the Schwarz Algorithm

, 2009
We investigate Schwarz’ domain decomposition algorithm as a tool for numerical zoom and compare it with the Subspace Correction Method. Quadrature error is investigated and the convergence of Schwarz’ algorithm is sketched for non matching grids. The methods are also compared numerically.
Hecht, Frédéric, Lozinski, Alexei, Pironneau, Olivier   +2 more
openaire   +5 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Numerical Algorithms for Acoustic Wave Propagation in Pipelines via a Class of Stochastic Partial Differential Systems

Mathematics
A class of partial differential equations with random noise is employed to model the pipe acoustic system. A high-precision compact differential scheme is constructed for its solution. To ensure numerical stability, a buffer layer technique is applied to
Xinrong Cong, Longsuo Li, Shuxia Zhang
doaj   +1 more source

Connections Between Numerical Algorithms for PDEs and Neural Networks. [PDF]

J Math Imaging Vis, 2023
Alt T, Schrader K, Augustin M, Peter P, Weickert J.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A Novel Magnetic Update Operator for Quantum Evolutionary Algorithms

, 2010
Quantum Evolutionary Algorithms (QEA) are novel algorithms proposed for class of combinatorial optimization problems. The probabilistic representation of possible solutions in QEA helps the q-individuals to represent all the search space simultaneously ...
Tayarani Najaran, Mohammad, Prugel-Bennett, Adam   +1 more
core   +1 more source

Numerical Calculation of Finite-Time Ruin Probabilities in the Dual Risk Model

Risks
In the dual risk model, while the ultimate ruin probability has an exact and straightforward formula, the mathematics becomes significantly more complex when considering a finite time horizon, and the literature on this topic is scarce.
Rui M. R. Cardoso, Andressa C. O. Melo
doaj   +1 more source