Results 101 to 110 of about 28,044,371 (256)

Numerical analysis

Scholarpedia, 2007
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Professor Ion Păvăloiu at his 75th anniversary

Journal of Numerical Analysis and Approximation Theory, 2015
Emil Cătinaș, Costică Mustăța
doaj   +2 more sources

Hydraulic Asymmetries for Biological and Bioinspired Valves in Tubular Channels: A Numerical Analysis. [PDF]

Biomimetics (Basel)
Varnier F, Norouzikudiani R, Corsi G, Agostinelli D, Levin I, DeSimone A.   +5 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

In memoriam professor Dimitrie D. Stancu, honorary member of the Romanian Academy

Journal of Numerical Analysis and Approximation Theory, 2014
Ion Păvăloiu, Emil Cătinaş
doaj   +2 more sources

Thermal Management of SSAW Acoustofluidic Devices: Experimental and Numerical Analysis. [PDF]

Nanomaterials (Basel)
Megalinskii A, Barteneva NS, Tikhonov A.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The international conference 'Semicentennial T. Popoviciu Institute of Numerical Analysis', May 7-10, 2008

Journal of Numerical Analysis and Approximation Theory, 2008
Ion Păvăloiu, Emil Cătinaş
doaj   +2 more sources

Numerical analysis and optimization of continuous texture geometries in thermo-hydrodynamic journal bearings. [PDF]

Sci Rep
Keshk OA, ELGamal H, Mokhiamar O, Saleh AM.   +3 more
europepmc   +1 more source