Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Professor Ion Păvăloiu at his 70th anniversary
Journal of Numerical Analysis and Approximation Theory, 2009 Emil Cătinaş, Costică Mustăţa
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Numerical analysis, spectral graph theory, orthogonal polynomials and quantum algorithms. [PDF]
Philos Trans A Math Phys Eng SciMinenkova A, Mograby G, Zhan H.
europepmc +1 more source
Discussion: “Numerical Analysis of Crack Propagation in Cyclic-Loaded Structures” (Forman, R. G., Kearney, V. E., and Engle, R. M., 1967, ASME J. Basic Eng., 89, pp. 459–463) [PDF]
, 1967 D. R. Miller
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Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Introduction to Numerical Analysis, by C. -E. Fröberg. Addison-Wesley Publishing Co., Inc., Reading, Mass., 1965, x + 340 pages, $8.95. [PDF]
, 1967 K. W. Smillie
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Numerical analysis of micropolar hybrid nanofluid
Applied Nanoscience, 2018 M. Subhani, S Nadeem
semanticscholar +1 more source
Numerical analysis of squeal instability
, 2005 The name “brake squeal” groups a large set of high frequency sound emissions from brake systems, generated during the braking phase and characterized by a periodic or harmonic spectrum. This paper presents two different numerical approaches to identify the mechanism bringing to the dynamic instability, producing squeal noise.
MASSI, Francesco, BAILLET L.
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