Results 71 to 80 of about 660,303 (296)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

On an Aitken type method

open access: yesJournal of Numerical Analysis and Approximation Theory, 2007
In this note we study the convergence of a generalized Aitken type method for approximating the solutions of nonlinear equations in \({\mathbb R}\). We obtain conditions which assure monotone convergence of the generated sequences.
Ion Păvăloiu, Emil Cătinaş
doaj   +2 more sources

On some interpolatory iterative methods for the second degree polynomial operators (II)

open access: yesJournal of Numerical Analysis and Approximation Theory, 1999
Not available.
Emil Cătinaş, Ion Păvăloiu
doaj  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Numerical analysis in nonlinear viscoelasticity

open access: yesComputers & Mathematics with Applications, 1980
AbstractThe well-known Volterra integral equation in linear viscoelasticity is treated to characterize the response of nonlinear viscoelastic materials. In this context, a procedure is presented which includes a differential approximation of the time-dependent kernel and an optimization procedure and leads to an optimum selection of certain parameters ...
openaire   +4 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

On the Heron's method for approximating the cubic root of a real number

open access: yesJournal of Numerical Analysis and Approximation Theory, 1997
Not available.
Dan Luca, Ion Păvăloiu
doaj  

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