Results 21 to 30 of about 311,094 (206)

A cell-based smoothed finite element method for kinematic limit analysis [PDF]

, 2010
This paper presents a new numerical procedure for kinematic limit analysis problems, which incorporates the cell-based smoothed finite element method with second-order cone programming.
Anderheggen, Andersen, Andersen, Andersen, Andersen, Belytschko, Belytschko, Belytschko, Bordas, Bottero, Capsoni, Chaaba, Chen, Chen, Chen, Chen, Christiansen, Christiansen, Ciria, Dai, Flanagan, Gaydon, Gross-Weege, Huh, Huh, Jiang, Krabbenhoft, Le, Le, Le, Le, Liu, Liu, Liu, Liu, Liu, Liu, Lyamin, Makrodimopoulos, Makrodimopoulos, Munoz, Nagtegaal, Nguyen, Nguyen-Thanh, Nguyen-Thoi, Nguyen-Xuan, Nguyen-Xuan, Nguyen-Xuan, Nguyen-Xuan, Nguyen-Xuan, Prandtl, Sloan, Smith, Sze, Tin-Loi, Vicente da Silva, Wang, Yoo, Zouain, Zouain   +59 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

On The Development Of Finite Volume Methods For Computational Solid Mechanics [PDF]

, 2007
Since its initial development as a tool for structural analysis around the mid-fifties the Finite Element Method (FEM) has evolved to become the most popular and used method in modern Computational Solid Mechanics.
Idelsohn, Sergio Rodolfo, Limache, Alejandro Cesar   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A mathematical model of the gravitational potential of the planet taking into account tidal deformations

Российский технологический журнал
Objectives. This paper investigates the gravitational potential of a viscoelastic planet moving in the gravitational field of a massive attracting center (star), a satellite and one or more other planets moving in Keplerian elliptical orbits relative to ...
А. V. Shatina, A. S. Borets
doaj   +1 more source

Bottom changes in coastal areas with complex shorelines [PDF]

, 2017
A model for the sea-bottom change simulations in coastal areas with complex shorelines is proposed. In deep and intermediate water depths, the hydrodynamic quantities are calculated by numerically integrating the contravariant Boussinesq equations ...
Cannata, Giovanni, Gallerano, Francesco, Scarpone, Simone   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Solid-fluid dynamics of yield-stress fluids

, 2014
On the example of two-phase continua experiencing stress induced solid-fluid phase transitions we explore the use of the Euler structure in the formulation of the governing equations.
Grmela, Miroslav, Peshkov, Ilya, Romenski, Evgeniy   +2 more
core   +1 more source

Layout optimization for multi-bi-modulus materials system under multiple load cases [PDF]

, 2016
Financial support from the National Natural Science Foundation of China (Grant No. 51179164) and the Australian Research Council (Grant No.
Cai, Kun, Cao, Jing, Qin, Qing-Hua, Shi, Jiao, Wang, Zhenzhong   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source