Results 21 to 30 of about 32,647 (196)

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Space-time least-squares isogeometric method and efficient solver for parabolic problems

, 2019
In this paper, we propose a space-time least-squares isogeometric method to solve parabolic evolution problems, well suited for high-degree smooth splines in the space-time domain. We focus on the linear solver and its computational efficiency: thanks to
Montardini, Monica, Negri, Matteo, Sangalli, Giancarlo, Tani, Mattia   +3 more
core   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Bioinspired Shape‐Memory Hook Fasteners With Programmable Interlocking and Silent Release

Advanced Engineering Materials, EarlyView.
Bioinspired hook fasteners made from epoxy shape‐memory polymers are shown to switch between strong, secure attachment and gentle, silent release when heated. By combining programmable geometry and material response, these adaptive fasteners outperform commercial systems in strength and noise control, enabling new solutions for robotics, medical ...
Maria I. Vallejo Ciro, Manuel J. Carvajal Loaiza, Rahaf Homssi, Vanessa Restrepo   +3 more
wiley   +1 more source

Formulation of an isogeometric shell element for crash simulation [PDF]

, 2013
In this paper, we propose, for the isogeometric analysis, a shell model based on a degenerated three dimensional approach. It uses a first order kinematic description in the thickness with transverse shear (Reissner-Mindlin theory).
Adam, Cédric, Bouabdallah, Salim, Maitournam, Habibou, Zarrouk, Malek   +3 more
core  

Meta‐Rod Mechanical Metamaterials With Programmable Reconfiguration

Advanced Functional Materials, EarlyView.
Existing mechanical metamaterials achieve programmable large deformations in planar square or cubic configurations, restricted by required complex boundary conditions. This research proposes a 1D metamaterial, Meta‐rod, with linear, bending, twisting, area, and volume deformation modes.
Atharva Pande, Lyes Kadem, Hang Xu
wiley   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Improving convergence in smoothed particle hydrodynamics simulations without pairing instability

, 2012
The numerical convergence of smoothed particle hydrodynamics (SPH) can be severely restricted by random force errors induced by particle disorder, especially in shear flows, which are ubiquitous in astrophysics.
Abel, Bochner, Cabezón, Cullen, Fulk, Gingold, Gray, Gresho, Hall, Herant, Heß, Hossam Aly, Irwin, Liska, Lucy, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Nelson, Phillips, Price, Rasio, Read, Read, Rosswog, Schoenberg, Schüßler, Silverman, Sod, Springel, Springel, Swegle, Thomas, Walter Dehnen, Wendland, Wendland   +41 more
core   +1 more source

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

Advanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph, Maria Rosa Gigliobianco, Cristina Minnelli, Paolo Moretti, Francesco Spinozzi, Giovanna Mobbili, Sara Pistolesi, Cristina Casadidio, Gabriella Teti, Roberta Censi, Stefano Antonio Gattone, Piera Di Martino   +11 more
wiley   +1 more source

Solving the Monge-Amp\`ere Equations for the Inverse Reflector Problem

, 2014
The inverse reflector problem arises in geometrical nonimaging optics: Given a light source and a target, the question is how to design a reflecting free-form surface such that a desired light density distribution is generated on the target, e.g., a ...
Brix, Kolja, Hafizogullari, Yasemin, Platen, Andreas   +2 more
core   +1 more source