Results 101 to 110 of about 2,121,081 (246)

Influence of sensitive pose errors on tooth deviation of cylindrical gear in power skiving

open access: yesAdvances in Mechanical Engineering, 2019
Power skiving is a modern and productive method in the manufacturing of cylindrical internal gears and external gears. However, pose errors of workpiece and cutter are caused by clamping, cutting force, and deformation of heat, which make the tooth ...
Erkuo Guo   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Pointwise-in-time error estimates for an optimal control problem with subdiffusion constraint

open access: yes, 2017
In this work, we present numerical analysis for a distributed optimal control problem, with box constraint on the control, governed by a subdiffusion equation which involves a fractional derivative of order $\alpha\in(0,1)$ in time.
Jin, Bangti, Li, Buyang, Zhou, Zhi
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Overcoming the strength-ductility trade-off in 300 M steel via spatially-controlled heterostructure design

open access: yesJournal of Materials Research and Technology
A paradigm for spatially-controlled heterostructure design is proposed to overcome the strength-ductility trade-off in ultra-high-strength 300 M steel fabricated via laser powder bed fusion (LPBF).
Yuang Dong   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy