Results 91 to 100 of about 473,529 (307)
A numerical study of strained three-dimensional wall-bounded turbulence
, 2000 Channel flow, initially fully developed and two-dimensional, is subjected to mean strains that emulate the effect of rapid changes of streamwise and spanwise pressure gradients in three-dimensional boundary layers, ducts, or diffusers.
Coleman, G.N., Spalart, P.R., Kim, J.
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Numerical experiments on string cosmology [PDF]
Nuclear Physics B, 1996 We investigate some classical aspects of fundamental strings via numerical experiments. In particular, we study the thermodynamics of a string network within a toroidal universe, as a function of string energy density and space dimensionality. We find that when the energy density of the system is low, the dominant part of the string is in the form of ...
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Towards a standardization of non-symbolic numerical experiments: GeNEsIS, a flexible and user-friendly tool to generate controlled stimuli. [PDF]
Behav Res Methods, 2022 Zanon M +3 more
europepmc +1 more source
High-order numerical methods for scattering problems
, 2021 Scattering problems are ubiquitous in scientific and engineering applications. These problems can often be straightforwardly modeled using relatively simple linear partial differential equations, such as the Helmholtz equation.
Gopal, Abinand
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Applied Mathematics in Science and EngineeringAn artificial example of a coupled system of three nonlinear partial differential equations generalizing 2D thermoelastic vibrations, is used to demonstrate the effectiveness, as well as the limitations, of a non iterative direct procedure in data ...
Alfred S. Carasso
doaj +1 more source
A numerical investigation of constant-volume non-Boussinesq density currents [PDF]
, 2010 The time-dependent behaviour of non-Boussinesq high-Reynolds-number density currents of density ρc, released from a lock of height h₀ and length x₀ into a ambient of height H and density ρₐ, is considered. We use two dimensional Navier-Stokes simulations
Ungarish, Marius +2 more
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