Results 161 to 170 of about 975,461 (312)

Computer algebra and transputers applied to the finite element method [PDF]

open access: yes, 1992
Recent developments in computing technology have opened new prospects for computationally intensive numerical methods such as the finite element method.
Barbier, Christine, Barbier, C
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Numerical Simulation of a Marine Current Turbine in Turbulent Flow

open access: yes, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorThe marine current turbine (MCT) is an exciting proposition for the extraction of ...
Xin, Bai
core  

Numerical simulation of incompressible and compressible flow. [PDF]

open access: yes, 1989
This thesis describes the development of a numerical solution procedure which is valid for both incompressible flow and compressible flow at any Mach number.
Yang, Zhiyan, Yang, Z
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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