Results 201 to 210 of about 975,461 (312)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Survey on the Numerical Methods for ODE's Using the Sequence of Successive Approximations
, 2005 Here we present the error estimations in the numerical methods for Cauchy problems corresponding to ODE’s, which use the sequence of successive approximations and quadrature rules such as trapezoidal rule and perturbed trapezoidal ...
Bica, Alexandru Mihai
core
Analysis of thermomechanical stresses in dual compound thick cylinders under asymmetric loads: An analytical and numerical method. [PDF]
HeliyonDas P, Islam MA, Mondal D.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Some modifications of MPS method for incompressible free surface flow
As a Lagrangian mesh-free method, the Moving Particle Semi-implicit (MPS)[1] method is very suitable for simulating violent flows, such as breaking waves on free surface.
Xing, J.T. +3 more
core
Author Correction: Supersonic turbulent flow simulation using a scalable parallel modal discontinuous Galerkin numerical method. [PDF]
Sci Rep, 2020 Houba T +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Numerical Analysis on Natural Convection Heat Transfer in a Single Circular Fin-Tube Heat Exchanger (Part 1): Numerical Method. [PDF]
Entropy (Basel), 2020 Lee JH, Shin JH, Chang SM, Min T.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source