Results 21 to 30 of about 4,613 (247)

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

A regularization–discretization strategy for weakly singular Fredholm integral equations: a Tikhonov–Legendre approach

Open Mathematics
This study presents a new computational technique for solving weakly singular Fredholm integral equations of the first kind, based on a regularization–discretization strategy that combines Tikhonov regularization with Legendre spectral projection methods.
Bechouat Tahar, Boussetila Nadjib, Bağlan İrem, Lakhdari Abdelghani, Abdeljawad Thabet   +4 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Extension of the First-Order Recursive Filters Method to Non-Linear Second-Kind Volterra Integral Equations

Mathematics
A new numerical method for solving Volterra non-linear convolution integral equations (NLCVIEs) of the second kind is presented in this work. This new approach, named IIRFM-A, is based on the combined use of the Laplace transformation, a first-order ...
Rodolphe Heyd
doaj   +1 more source

Numerical and Analytical Solutions of Space-Time Fractional Partial Differential Equations by Using a New Double Integral Transform Method

Iraqi Journal of Science, 2023
  This work discusses the beginning of fractional calculus and how the Sumudu and Elzaki transforms are applied to fractional derivatives. This approach combines a double Sumudu-Elzaki transform strategy to discover analytic solutions to space-time fractional partial differential equations in Mittag-Leffler functions subject to initial and boundary ...
Mohammed G. S. AL-Safi, Wurood R. Abd AL-Hussein, Rand Muhand Fawzi   +2 more
openaire   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

A Novel Fractional Integral Transform-Based Homotopy Perturbation Method for Some Nonlinear Differential Systems

Fractal and Fractional
In this work, we introduce an innovative analytical–numerical approach to solving nonlinear fractional differential equations by integrating the homotopy perturbation method with the new integral transform.
Aisha F. Fareed, Emad A. Mohamed, Mokhtar Aly, Mourad S. Semary   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Modified Degenerate Kernel Method for the Multi-Dimensional Fredholm Integral Equations of the Second Kind

پژوهش‌های ریاضی, 2020
Introduction For the scientific study of a natural phenomenon it must be modeled. The resulting model is often expressed as a differential equation (DE), an integral equation (IE) or an integro-differential equation (IDE) or a system of these. Therefore,
Ahmad Molabahrami
doaj