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dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source
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Numerical modeling for plasmonics

International Journal of Applied Electromagnetics and Mechanics, 2011
This contribution is a review paper, concerning mainly the research work made by the authors, about the numerical modeling, in the frequency domain, of both surface and bulk plasmon oscillations induced in metallic nanoparticles with arbitrary shapes by an external electromagnetic field.
G. MIANO   +2 more
openaire   +4 more sources

Numerical Modelling

2018
This chapter deals with the problem of modelling the behaviour of massive concrete structures. In the last decades, the developments in the field of computational mechanics were significant, so nowadays several numerical techniques are available to this goal, depending on the scale level considered but also on which phenomena/processes are taken into ...
Pesavento F.   +4 more
openaire   +2 more sources

NUMERICAL MODELS | Methods

2003
Numerical modeling of the atmosphere is challenging because of the enormous range of space and timescales involved, and because many qualitative features, such as balance and conservation, must be accurately captured. We discuss here a number of topics that have proved important historically in the development of numerical models of the atmosphere ...
openaire   +1 more source

Numerical modelling

2021
Abstract Modelling and tuning of muon beamlines can be carried out using matrix techniques from optics, or via ray tracing methods. Monte Carlo methods for determining the muon stopping profile allow optimal degrader thicknesses to be computed, and pressure- cell and low-energy measurements to be planned.
openaire   +1 more source

Numerical Modeling

2005
Vivian Gornitz   +14 more
  +4 more sources

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