Results 151 to 160 of about 568,578 (262)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Numerical model for electrogenic transport by the ATP-dependent potassium pump KdpFABC. [PDF]

Biophys Rep (N Y)
Hussein A, Zhang X, Stokes DL.
europepmc   +1 more source

Urban Flooding Prediction Method Based on the Combination of LSTM Neural Network and Numerical Model. [PDF]

Int J Environ Res Public Health, 2023
Chen J, Li Y, Zhang C, Tian Y, Guo Z.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Noise Levels Due to Commercial and Leisure Activities in Urban Areas: Experimental Validation of a Numerical Model Fed with Crowd Density Estimation Using Computer Vision. [PDF]

Sensors (Basel)
Ramón-Turner Ó, Bordón JDR, González-Rodríguez A, Lorenzo-Navarro J, Castrillón-Santana M, Álamo GM, Quevedo-Reina R, Romero-Sánchez C, Ester-Sánchez AT, Medina C, García F, Maeso O, Aznárez JJ.   +12 more
europepmc   +1 more source

A Numerical Model for Investigating the Effect of Viscoelasticity on the Partial Slip Solution. [PDF]

Materials (Basel), 2022
Wang D, de Boer G, Ghanbarzadeh A.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Maximizing the efficiency of single-stage partial nitrification/Anammox granule processes and balancing microbial competition using insights of a numerical model study. [PDF]

Water Environ Res
Elsayed A, Lee T, Kim Y.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Detailed Numerical Model for a New Composite Slim-Floor Slab System. [PDF]

Materials (Basel)
Dudziak S, Lewiński PM.
europepmc   +1 more source