Results 71 to 80 of about 568,578 (262)
Numerical analysis of the effect of double-skin façade types on fire behaviour
GrađevinarThis study investigated the fire safety effect of double-skin façade (DSF) types that vary according to natural airflow through a numerical model. According to the cavity design, four DSF systems-multi-storey, corridor type, shaft type, and window-box ...
Mehmet Akif Yıldız +1 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Estimation of Coastal Currents Using a Soft Computing Method: A Case Study in Galway Bay, Ireland
Journal of Marine Science and Engineering, 2019 In order to obtain forward states of coastal currents, numerical models are a commonly used approach. However, the accurate definition of initial conditions, boundary conditions and other model parameters are challenging.
Lei Ren +5 more
doaj +1 more source
Colored Visualisation for Numerical Modelling. [PDF]
, 2001 In this paper scalar and vector data are visualised by suited colour scales based on perceptive and uniform colour models. Using opportune colour scales, colour information is created from the two-dimensional scalar data computed at different time steps.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hydrodynamic modeling of stratified estuary: case study of the Jadro River (Croatia)
Journal of Hydrology and Hydromechanics, 2015 The Jadro River with total length of 4.3 km and average annual discharge of 7.9 m3 s-1 is a relatively small river on the east coast of the Adriatic Sea, close to Split.
Ljubenkov Igor
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source