Results 41 to 50 of about 11,269 (260)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

A Nonlinear Crack Model for Concrete Structure Based on an Extended Scaled Boundary Finite Element Method

Applied Sciences, 2018
Fracture mechanics is one of the most important approaches to structural safety analysis. Modeling the fracture process zone (FPZ) is critical to understand the nonlinear cracking behavior of heterogeneous quasi-brittle materials such as concrete.
Jian-bo Li, Xin Gao, Xing-an Fu, Chenglin Wu, Gao Lin   +4 more
doaj   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Numerical modelling of interaction of cemented natural fractures and hydraulic fractures

Scientific Reports
Cemented natural fractures (CNFs) are commonly found in unconventional shale and tight sandstone reservoirs. During the process of hydraulic fracturing, CNFs can affect the propagation of hydraulic fractures and thus impact oil and gas production. However, the interaction behavior between CNFs and hydraulic fractures is still unclear.
Haiyang Wang, Peiyao Xiao, Desheng Zhou, Qingqing Wang   +3 more
openaire   +3 more sources

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

Adaptive phase field simulation of quasi-static crack propagation in rocks

Underground Space, 2018
In this study, we present an adaptive phase field method (APFM) for modeling quasi-static crack propagation in rocks. Crack initiation due to positive strains is considered, and a numerical simulation is implemented using a commercial software, COMSOL ...
Shuwei Zhou, Xiaoying Zhuang
doaj   +1 more source

A numerical model for prediction of creep fracture

Materials Science and Engineering, 1987
Abstract A numerical model for the prediction of tertiary creep and creep ductility is proposed. The model is based on the Kachanov damage law and a growth law for grain boundary cavities. On the assumptions that all cavities nucleate on loading and that they all grow at the same rate, the creep damage parameter and, ultimately, the creep curve ...
J.S. Wang, W.D. Nix
openaire   +1 more source

Numerical modelling of hip fracture patterns in human femur [PDF]

Computer Methods and Programs in Biomedicine, 2019
Hip fracture morphology is an important factor determining the ulterior surgical repair and treatment, because of the dependence of the treatment on fracture morphology. Although numerical modelling can be a valuable tool for fracture prediction, the simulation of femur fracture is not simple due to the complexity of bone architecture and the numerical
Miguel Marco, Eugenio Giner, José Ramón Caeiro-Rey, Maria Henar Miguelez, Ricardo Larraínzar-Garijo   +4 more
openaire   +4 more sources

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source