Results 231 to 240 of about 891,020 (273)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
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Numerical modeling for plasmonics
International Journal of Applied Electromagnetics and Mechanics, 2011This contribution is a review paper, concerning mainly the research work made by the authors, about the numerical modeling, in the frequency domain, of both surface and bulk plasmon oscillations induced in metallic nanoparticles with arbitrary shapes by an external electromagnetic field.
G. MIANO +2 more
openaire +4 more sources
2018
This chapter deals with the problem of modelling the behaviour of massive concrete structures. In the last decades, the developments in the field of computational mechanics were significant, so nowadays several numerical techniques are available to this goal, depending on the scale level considered but also on which phenomena/processes are taken into ...
Pesavento F. +4 more
openaire +2 more sources
This chapter deals with the problem of modelling the behaviour of massive concrete structures. In the last decades, the developments in the field of computational mechanics were significant, so nowadays several numerical techniques are available to this goal, depending on the scale level considered but also on which phenomena/processes are taken into ...
Pesavento F. +4 more
openaire +2 more sources
2003
Numerical modeling of the atmosphere is challenging because of the enormous range of space and timescales involved, and because many qualitative features, such as balance and conservation, must be accurately captured. We discuss here a number of topics that have proved important historically in the development of numerical models of the atmosphere ...
openaire +1 more source
Numerical modeling of the atmosphere is challenging because of the enormous range of space and timescales involved, and because many qualitative features, such as balance and conservation, must be accurately captured. We discuss here a number of topics that have proved important historically in the development of numerical models of the atmosphere ...
openaire +1 more source