Results 241 to 250 of about 662,340 (308)

Slab tearing and its surface signals controlled by passive margin strength. [PDF]

Nat Commun
Maiti G, Andrić-Tomašević N, Balázs A, Eskens LHJ, Gerya T.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Numerical and experimental investigation of compaction-induced load effects on reinforced earth walls with rigid and flexible facings. [PDF]

Sci Rep
Ahmadi H.
europepmc   +1 more source

Multiscale numerical simulation based on Caflisch model to interpret power-induced quenching for sonochemical reactions. [PDF]

Ultrason Sonochem
Hayashi R, Yamamoto T.
europepmc   +1 more source

Stochastic modeling of pneumonia transmission dynamics and implications for public health control. [PDF]

Front Public Health
Raza A, Lampart M, Sumelka W, Rocha EM, Alruwaili F, Fadhal E.   +5 more
europepmc   +1 more source

Linguistic experiential priors account for notation-dependent numerical representations. [PDF]

Cognition
Anceresi G, Zdanowski KF, Marelli M, Henik A, Rinaldi L.   +4 more
europepmc   +1 more source

A New Insight into the Threshold and Oscillatory Regimes in Plant-Pathogen Models: A Nutrient-Driven Approach. [PDF]

Bull Math Biol
Damay DP, Peace A.
europepmc   +1 more source

Integrating physical modeling with artificial intelligence for predicting fish survival zones in polluted rivers to maintain a sustainable aquaculture industry. [PDF]

Sci Rep
El-Sattar HKA, Elshambakey M, Saleh A, Antar S.   +3 more
europepmc   +1 more source