Results 261 to 270 of about 2,340,836 (318)

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Equality of higher numerical ranges of matrices and a conjecture of Kippenhahn on Hermitian pencils

, 1998
Chi-Kwong Li, Ilya M. Spitkovsky, Sudheer Shukla   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Optimization of stope dimensions using response surface method coupling a hybrid chaos-genetic algorithm. [PDF]

Sci Rep
Lan M, Jia H, Ma J.
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Numerical Analysis of the Load-Bearing Capacity of a Thin-Walled Perforated Beam Cooperating with Chipboard Panels in a Structural System. [PDF]

Materials (Basel)
Denisiewicz A, Socha T, Kula K, Błażejewski W, Wyjadłowski M.   +4 more
europepmc   +1 more source

A Possible Link of Aerosol and Cloud Radiations to Asian Summer Monsoon and Its Implication in Long-range Numerical Weather Prediction

, 1998
Toshiki Iwasaki, H. Kitagawa
openalex   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Performance of Large Language Models in Numerical Versus Semantic Medical Knowledge: Cross-Sectional Benchmarking Study on Evidence-Based Questions and Answers.

J Med Internet Res
Avnat E, Levy M, Herstain D, Yanko E, Ben Joya D, Tzuchman Katz M, Eshel D, Laros S, Dagan Y, Barami S, Mermelstein J, Ovadia S, Shomron N, Shalev V, Abdulnour RE.   +14 more
europepmc   +1 more source

Collaborative optimization of the Mathews stability graph method and numerical simulation for the limit exposure area in stope. [PDF]

Sci Rep
You C, Hu J, Li J, Zhang J, Qi Z.
europepmc   +1 more source