Results 91 to 100 of about 283,918 (290)

The utility and validity of pain intensity rating scales for use in developing countries

PAIN Reports, 2018
. Introduction:. Pain intensity is the domain most often assessed in pain research. Although the Numerical Rating Scale is recommended for use in western countries, the utility and validity of this scale, relative to others, has not been established in ...
Anupa Pathak, Saurab Sharma, Mark P. Jensen   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transcutaneous Slowly Depolarizing Currents Elicit Pruritus in Patients with Atopic Dermatitis

Acta Dermato-Venereologica, 2020
Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patients ...
Roman Rukwied, Mark Schnakenberg, Hans Jürgen Solinkski, Martin Schmelz, Elke Weisshaar   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An Overview of The Spinal Metastasis Pain with Opioid Therapy and The Affecting Factor

Indonesian Journal of Cancer
Background: Spinal metastasis is the most frequent type of spinal tumor. Opioid is the first line of treatment for cancer pain despite a multitude of side effects.
Joice Rosewitasari Aryanti Djohansjah, Rini Andriani, Tiara Aninditha, Henry Riyanto Sofyan   +3 more
doaj   +1 more source

Validation of a Comprehensive Set of Pruritus Assessment Instruments: The Chronic Pruritus Tools Questionnaire PRURITOOLS

Acta Dermato-Venereologica, 2019
Few studies have validated standard measurement instruments for evaluation of chronic pruritus. The Chronic Pruritus Tools Questionnaire PRURITOOLS assembles a set of instruments for the assessment of pruritus, such as the visual analogue scale ...
Emely Verweyen, Sonja Ständer, Kiana Kreitz, Inga Höben, Nani Osada, Marvin Gernart, Claudia Riepe, Manuel Pereira, Christine Blome, Matthias Augustin, Claudia Zeidler   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Correlation between the Likert Scale and the Numeric Rating Scale for Evaluating Knee Pain

The Journal of Korean Knee Society, 2011
목적: 슬관절 동통을 평가하는데 흔히 사용되는 미국슬관절학회 슬관절 점수에 포함된 Likert 척도의 한글 번역판을 숫자 등급 척도(numeric rating scale, NRS)를 사용하여 검정하고자 하였다. 대상 및 방법: 2008년 6월부터 2009년 6월까지 본원에서 슬관절 전치환술을 시술받기 위해 입원한 환자 98명(제1군), 슬관절 전치환술 후 1년 이상(범위: 1-5년) 추시한 환자 141명(제2군), 슬관절염에 대하여 보존적 치료중인 환자 111명(제3군)의 슬관절 동통의 정도를 Likert 척도에 의한 동통의 정도와 NRS에 의한 동통 정도를 동시에 평가하여 두 척도 간의 상관관계를 Pearson 법을 이용하여
Choong-Hyeok Choi, Suk-Hwan Kim, Young-Seok Lee, Chang-Nam Kang   +3 more
openaire   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source