Results 151 to 160 of about 3,114,017 (331)

Learning about compact binary merger: The interplay between numerical relativity and gravitational-wave astronomy [PDF]

, 2008
Thomas W. Baumgarte, P. R. Brady, J. D. E. Creighton, Luis Lehner, Frans Pretorius, Ricky DeVoe   +5 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Towards a wave-extraction method for numerical relativity. IV. Testing the quasi-Kinnersley method in the Bondi-Sachs framework [PDF]

, 2006
Andrea Nerozzi, Marco Bruni, Virginia Re, Lior M. Burko   +3 more
openalex   +1 more source

Dynamical Boson Stars

Living Reviews in Relativity, 2012
The idea of stable, localized bundles of energy has strong appeal as a model for particles. In the 1950s, John Wheeler envisioned such bundles as smooth configurations of electromagnetic energy that he called geons, but none were found. Instead, particle-
Steven L. Liebling, Carlos Palenzuela
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Kilohertz Gravitational Waves From Binary Neutron Star Mergers: Numerical-relativity Informed Postmerger Model [PDF]

, 2022
M. Breschi, Sebastiano Bernuzzi, K. Chakravarti, Alessandro Camilletti, Aviral Prakash, Albino Perego   +5 more
openalex   +1 more source

Comparing Numerical Relativity and Perturbation Theory Waveforms for a Non-Spinning Equal-Mass Binary

Universe
Past studies have empirically demonstrated a surprising agreement between gravitational waveforms computed using adiabatic–driven–inspiral point–particle black hole perturbation theory (ppBHPT) and numerical relativity (NR) following a straightforward ...
Tousif Islam, Scott E. Field, Gaurav Khanna   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Self-force framework for transition-to-plunge waveforms

SciPost Physics
Compact binaries with asymmetric mass ratios are key expected sources for next-generation gravitational wave detectors. Gravitational self-force theory has been successful in producing post-adiabatic waveforms that describe the quasi-circular inspiral ...
Lorenzo Küchler, Geoffrey Compère, Leanne Durkan, Adam Pound
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source