Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An implicit Keller Box numerical scheme for the solution of fractional subdiffusion equations
, 2019 In this work, we present a new implicit numerical scheme for fractional subdiffusion equations. In this approach we use the Keller Box method [1] to spatially discretise the fractional subdiffusion equation and we use a modified L1 scheme (ML1), similar ...
Osman, S. A, Langlands, T. A. M.
core +1 more source
A new explicit numerical scheme for enhancement of heat transfer in Sakiadis flow of micro polar fluid using electric field. [PDF]
Heliyon, 2023 Nawaz Y +4 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On the construction of boundary preserving numerical schemes [PDF]
Monte Carlo Methods and Applications, 2016 Abstract Our aim in this note is to extend the semi-discrete technique by combine it with the split step method. We apply our new method to the Ait-Sahalia model and propose an explicit and positivity preserving numerical scheme.
openaire +3 more sources
An efficient numerical scheme for fractional host–parasite hyperparasite interaction model
Applied Mathematics in Science and EngineeringIn this paper, we analyse the unique characteristics of hyperparasites and discharge incidents in the initial stage of parasite populations. If hyperparasites are effectively developed in a population, they can play a crucial role in controlling host ...
Parveen Kumar +3 more
doaj +1 more source
An Efficient Numerical Scheme for Solving a Fractional-Order System of Delay Differential Equations. [PDF]
Int J Appl Comput Math, 2022 Kumar M.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
New Simplified High-Order Schemes for Solving SDEs with Markovian Switching Driven by Pure Jumps
AxiomsNew high-order weak schemes are proposed and simplified to solve stochastic differential equations with Markovian switching driven by pure jumps (PJ-SDEwMs).
Yang Li +3 more
doaj +1 more source
Layer resolving numerical scheme for singularly perturbed parabolic convection-diffusion problem with an interior layer. [PDF]
MethodsX, 2023 Kusi GR, Habte AH, Bullo TA.
europepmc +1 more source