Results 111 to 120 of about 142,525 (267)
A Two-Step High-Order Compact Corrected WENO Scheme
AlgorithmsIn this study, we introduce a novel 2-step compact scheme-based high-order correction method for computational fluid dynamics (CFD). Unlike traditional single-formula-based schemes, our proposed approach refines flux function values by leveraging results
Yong Yang +3 more
doaj +1 more source
Accurate numerical scheme for singularly perturbed parabolic delay differential equation. [PDF]
BMC Res Notes, 2021 Woldaregay MM, Duressa GF.
europepmc +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Production and dispersion of free radicals from transient cavitation Bubbles: An integrated numerical scheme and applications. [PDF]
Ultrason Sonochem, 2022 Peng K, Qin FGF, Jiang R, Qu W, Wang Q.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Hilbert schemes of hypersurfaces and numerical criterions.
MATHEMATICA SCANDINAVICA, 1985 The paper studies n-dimensional varieties in \({\mathbb{P}}^ N\) which are hypersurfaces in some linear subspace. These are called n-hypersurfaces. The first theorem in the paper states that if \(n>0\), then a subscheme of \({\mathbb{P}}^ N\) with the Hilbert polynomial of an n-hypersurface is indeed an n-hypersurface.
openaire +3 more sources