Results 211 to 220 of about 142,525 (267)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Deterministic and ANN-based modelling of measles transmission using real epidemiological data. [PDF]

Sci Rep
Shah K, Du C, Akgül A, Alshammari FS, Bajri SA, Khalifa HAE.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Numerical convergence of the scalar auxiliary variable method applied to nonlinear stiff string models. [PDF]

Nonlinear Dyn
Russo R, Ducceschi M, Bilbao S.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Optimization Research on Sensor Network Layout for Microseismic Monitoring Based on Location Error Analysis. [PDF]

Sensors (Basel)
Huang X, Li S, Dong L, Yang L.
europepmc   +1 more source

Research on dust control and ventilation parameter optimization in roadhead mining based on response surface methodology. [PDF]

PLoS One
Zhao X, Zhang Y, Ge J, Wang W, Bai Y, Yang D.   +5 more
europepmc   +1 more source

Convergence Analysis of Iterative Deep Learning Algorithms for Fully Nonlinear BSPDEs in Non-Markovian Utility Maximization. [PDF]

J Sci Comput
Ma J, Wu H, Zheng HH.
europepmc   +1 more source

Flow Characteristics of Unclassified Tailings Backfill Slurry and Optimization of Roof-Contact Backfilling Scheme. [PDF]

Materials (Basel)
Li H, Tan Y, Huang X, Zhang Z, Chen J, Deng Y.   +5 more
europepmc   +1 more source

A fast numerical integration scheme for clonal expansion processes on graphs. [PDF]

PLoS Comput Biol
Paterson C, Gao M, Hellier J, Luebeck G, Wedge DC, Bozic I.   +5 more
europepmc   +1 more source