Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Numerical solution of the eXtended Pom-Pom model for viscoelastic free surface flows
In this paper we present a finite difference method for solving two-dimensional viscoelastic unsteady free surface flows governed by the single equation version of the eXtended Pom-Pom (XPP) model. The momentum equations are solved by a projection method
Tome, Murilo F. +18 more
core +1 more source
Numerical simulation and design of semiconductor quantum dot-based lasers and amplifiers [PDF]
Numerical simulation and design of semiconductor quantum dot-based lasers and ...
Xu, Tianhong
core +1 more source
Dynamical Behavior of a Novel Impulsive Switching Model for HLB with Seasonal Fluctuations
This paper studies a new model for Huanglongbing with seasonal fluctuations. Switching coefficients and switching control schemes are considered in this model.
Shujing Gao +3 more
doaj +1 more source
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Development of a rotor model for the numerical simulation of helicopter exterior flow-fields
Includes bibliographical references (leaves 84-85).A numerical methodology is developed to model the effect of a rotor on the surrounding flow-field. The model calculates the time-averaged aerodynamic forces exerted on the air by the fan blades within ...
Hotchkiss, Paul
core
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Dynamic system simulation on the web [PDF]
Computer simulation is the discipline of designing a model of an actual or theoretical physical system, executing the model on digital computer, and analysing the execution output.
Mahbub, Khaled
core
Numerical simulation of flow field in water-pump sump and inlet suction pipe [PDF]
There are several important considerations in the design of a suction supply sump. It is imperative that the amount of turbulence and entrained air be kept to a minimum.
BOIS, Gérard +2 more
core +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source

