Results 91 to 100 of about 487,104 (268)

A Robust and Efficient Numerical Method for RNA-Mediated Viral Dynamics

open access: yesFrontiers in Applied Mathematics and Statistics, 2017
The multiscale model of hepatitis C virus (HCV) dynamics, which includes intracellular viral RNA (vRNA) replication, has been formulated in recent years in order to provide a new conceptual framework for understanding the mechanism of action of a variety
Vladimir Reinharz   +3 more
doaj   +1 more source

The numerical solution of elliptic and parabolic partial differential equations with boundary singularities

open access: yes, 1976
A general numerical method is described for the solution of linear elliptic and parabolic partial differential equations in the presence of boundary singularities.
Furzeland, RM, Crank, J
core  

Numerical solution of time fractional diffusion systems [PDF]

open access: yes, 2017
In this paper a general class of diffusion problem is considered, where the standard time derivative is replaced by a fractional one. For the numerical solution, a mixed method is proposed, which consists of a finite difference scheme through space and a
Kevin Burrage   +7 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Optimal Control Strategy on the Transmission Dynamics of Herpes Simplex Virus-II (HSV-II)

open access: yesApplications of Modelling and Simulation, 2021
In this paper, optimal control theory is applied to Herpes Simplex Virus-II transmission model given by a system of non-linear ordinary differential equations.
Eshetu Dadi Gurmu   +2 more
doaj  

Investigation of Wavenumber Domain Imaging Algorithm for Ground-Based Arc Array SAR

open access: yesSensors, 2017
Ground-based synthetic aperture radar (GB-SAR) has become an important technique for remote sensing deformation monitoring. However, most of the existing GB-SAR systems realize synthetic aperture by exploiting two closely spaced horn antennas to move ...
Zengshu Huang   +4 more
doaj   +1 more source

Numerical Solution of Dynamic Equilibrium Models under Poisson Uncertainty [PDF]

open access: yes
We propose a simple and powerful numerical algorithm to compute the transition process in continuous-time dynamic equilibrium models with rare events.
Timo Trimborn, Olaf Posch
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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