Results 101 to 110 of about 7,309,496 (268)
Identification of solidification process parameters
Computer Assisted Methods in Engineering and Science, 2017 In the paper, the identification problems connected with estimation of cast iron and mould thermophysical parameters are discussed. The additional information necessary to solve the problem results from the knowledge of cooling (heating) curves at the ...
Jerzy Mendakiewicz
doaj
MIXANDMIX: numerical techniques for the computation of empirical spectral distributions of population mixtures. [PDF]
Comput Stat Data Anal, 2020 Cordero-Grande L.
europepmc +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Direction-dependent calibration with image-domain gridding
Astronomy & AstrophysicsAims. Wide-field images made by radio interferometers are invariably affected by direction-dependent systematic effects such as the ionosphere or the beam pattern.
van der Tol Sebastiaan +3 more
doaj +1 more source
Numerical techniques to find optimal input parameters for achieving mean particles' temperature and axial velocity in atmospheric plasma spray process. [PDF]
Sci Rep, 2020 Batra RC, Taetragool U.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
New methods to improve the decontamination of slitless spectra
Astronomy & AstrophysicsThis paper proposes four new methods to decontaminate spectra of stars and galaxies resulting from slitless spectroscopy used in many space missions such as Euclid.
Bella M. +3 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source