Results 211 to 220 of about 690,215 (327)
Single‐cell RNA sequencing reveals that type 1 AIP exhibits increased amount and subtypes of B and plasma cells, particularly IgG4+ plasma cells, along with an expansion of Tfh and T helper CD4+ cells. Both AIP types share upregulation of HIF1A+ classical monocytes, which promote pancreatic fibrosis through increased visfatin production.
Deyu Zhang+23 more
wiley +1 more source
An Objective Technique for Verifying Sea Breezes in High-Resolution Numerical Weather Prediction Models [PDF]
Jonathan L. Case+4 more
openalex +1 more source
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang+10 more
wiley +1 more source
Actionable Forecasting as a Determinant of Biological Adaptation
A new framework reveals how biological systems can achieve precise adaptation by tracking an actionable target that combines the current optimal state with its rate of change. This approach, implemented through dynamics‐informed neural networks, demonstrates that predictive mechanisms like circadian rhythms become beneficial when environmental sensing ...
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
Use of Medium-Range Numerical Weather Prediction Model Output to Produce Forecasts of Streamflow [PDF]
Martyn Clark, Lauren E. Hay
openalex +1 more source
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu+12 more
wiley +1 more source
Adiabatic Invariance and Applications: From Molecular Dynamics to Numerical Weather Prediction [PDF]
Colin J. Cotter, Sebastian Reich
openalex +1 more source
Assessing species' vulnerabilities across geographical gradients is essential for biodiversity conservation under climate change. To address this challenge, the semi‐natural climate chamber across latitudes (SCCAL) is developed, a validated system capable of simulating thermal environments for ecological experiments without reliance on water or ...
Bao‐Jun Sun+15 more
wiley +1 more source