Results 211 to 220 of about 690,215 (327)

Unraveling the Microenvironment and the Pathogenic Axis of HIF‐1α–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single‐Cell Atlas

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
Single‐cell RNA sequencing reveals that type 1 AIP exhibits increased amount and subtypes of B and plasma cells, particularly IgG4+ plasma cells, along with an expansion of Tfh and T helper CD4+ cells. Both AIP types share upregulation of HIF1A+ classical monocytes, which promote pancreatic fibrosis through increased visfatin production.
Deyu Zhang   +23 more
wiley   +1 more source

An Objective Technique for Verifying Sea Breezes in High-Resolution Numerical Weather Prediction Models [PDF]

open access: bronze, 2004
Jonathan L. Case   +4 more
openalex   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Actionable Forecasting as a Determinant of Biological Adaptation

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
A new framework reveals how biological systems can achieve precise adaptation by tracking an actionable target that combines the current optimal state with its rate of change. This approach, implemented through dynamics‐informed neural networks, demonstrates that predictive mechanisms like circadian rhythms become beneficial when environmental sensing ...
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity

open access: yesAdvanced Science, EarlyView.
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu   +12 more
wiley   +1 more source

The Semi‐Natural Climate Chambers across Latitudes: A Broadly Applicable Husbandry and Experimental System for Terrestrial Ectotherms under Climate Change

open access: yesAdvanced Science, EarlyView.
Assessing species' vulnerabilities across geographical gradients is essential for biodiversity conservation under climate change. To address this challenge, the semi‐natural climate chamber across latitudes (SCCAL) is developed, a validated system capable of simulating thermal environments for ecological experiments without reliance on water or ...
Bao‐Jun Sun   +15 more
wiley   +1 more source

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