Results 41 to 50 of about 3,761 (200)

Coarse guidance by numerosity in visual search [PDF]

, 2018
In five experiments, we examined whether the number of items can guide visual focal attention. Observers searched for the target area with the largest (or smallest) number of dots (squares in Experiment 4 and "checkerboards” in Experiment 5) among ...
Krummenacher, Joseph, Reijnen, Ester, Wolfe, Jeremy   +2 more
core  

Spatial clustering and its effect on perceived clustering, numerosity, and dispersion [PDF]

, 2016
Human observers are able to estimate the numerosity of large sets of visual elements. The occupancy model of perceived numerosity in intermediate numerical ranges is based on overlapping regions of influence.
Bertamini, Marco, Hulleman, Johan, Scott-Samuel, Nicholas E., Zito, Michele   +3 more
core   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Color afterimages in autistic adults [PDF]

, 2016
It has been suggested that attenuated adaptation to visual stimuli in autism is the result of atypical perceptual priors (e.g., Pellicano and Burr in Trends Cogn Sci 16(10):504–510, 2012. doi:10.​1016/​j.​tics.​2012.​08.​009).
A Franklin, A Hellendoorn, A Kohn, A Oliva, AE Raftery, AE Robertson, AK Ludlow, American Psychiatric Association, Anna Franklin, C Fiorentini, C McCollough, C Wheatstone, CWG Clifford, D Kersten, D Wechsler, DC Knill, DW Kline, E Pellicano, E Pellicano, E Pellicano, E Pellicano, E Vul, Elizabeth Pellicano, ER Ritvo, G Anzures, G Lupyan, G Lupyan, G Powell, G Rhodes, H Pimperton, HC Koh, JA Walsh, JN Constantino, John Maule, Kirstie Stanworth, KJ Friston, L Ewing, L Ewing, L Jeffery, L Jeffery, L Jeffery, M Nishimura, M Nishimura, M Olkkonen, M Piazza, M Turi, M Vergeer, MA Webster, MB Cranwell, MD Rutherford, MEJ Masson, MM Bannert, MR Woodbury-Smith, N Kanwisher, NW Daw, P Heaton, P Lanthony, P Sinha, PJ Hills, Q Zaidi, R Cook, R Lier van, RP Lawson, S Anstis, S Baron-Cohen, S Cruys Van de, S Ishihara, ST Kover, T Fujita, T Hansen, T Karaminis, World Health Organization, Z Dienes   +72 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Two brains in action: joint-action coding in the primate frontal cortex [PDF]

, 2019
Daily life often requires the coordination of our actions with those of another partner. After sixty years (1968-2018) of behavioral neurophysiology of motor control, the neural mechanisms which allow such coordination in primates are unknown. We studied
Battaglia-Mayer, A, Ferrari-Toniolo, S, Visco-Comandini, F   +2 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A developmental model of number representation [PDF]

, 2017
We delineate a developmental model of number representations. Notably, developmental dyscalculia (DD) is rarely associated with an all-or-none deficit in numerosity processing as would be expected if assuming abstract number representations.
Kaufmann, Liane, Kucian, Karin
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source