Results 101 to 110 of about 13,002 (311)
Animal Models and Experimental Medicine, EarlyView.We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li +15 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu +11 more
wiley +1 more source
MedEdPORTAL, 2016 Introduction Approximately 1% of all children born in the United States suffer from congenital heart disease, and 25% of those affected are born with critical congenital heart disease requiring surgical intervention.
Desiree Aird +2 more
doaj +1 more source
Mucosal‐associated invariant T cells in rheumatic diseases.
Arthritis &Rheumatology, Accepted Article.Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor (TCR) and restriction by the MHC class I‐related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines. Upon activation, MAIT cells rapidly produce pro‐inflammatory cytokines,
Manon Lesturgie‐Talarek +7 more
wiley +1 more source
Ecotoxicology and Environmental Safety, 2021 Toluene and xylene are common components of surgical smoke, whereas hippuric acid (HA) and methylhippuric acid (MHA) are the products of toluene and xylene metabolism in humans, respectively.
Chun-Hui Chiu +5 more
doaj
Kaohsiung Journal of Medical Sciences, 2015 The prevalence of intravenous (IV) catheter-related infections is 0.5 per 1000 device days, and these infections cause tenderness, erythema, swelling and phlebitis. Catheter-related bloodstream infections (CRBSI) may independently increase hospital costs
Po-Chun Chiu +6 more
doaj +1 more source
Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways
Arthritis &Rheumatology, Accepted Article.Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu +17 more
wiley +1 more source
Critical Debate on Establishing a Scheme for Nurse Anesthetists in Japan
Acta Anaesthesiologica Taiwanica, 2009 For decades, a chronic shortage of anesthesiologists in Japan has been a serious problem. According to a personal survey conducted from 2002 to 2006 by Koichi Tsuzaki, MD (Associate Professor of Anesthesiology, Keio University School of Medicine, Tokyo Japan), more than one million surgical procedures required general anesthesia while only 6207 ...
Yukihide Koyama, Takahisa Goto
openaire +3 more sources
The Community of Nursing: Moral Friends, Moral Strangers, Moral Family [PDF]
, 2008 Unlike bioethicists who contend that there is a morality common to all, H. Tristan Engelhardt (1996) argues that, in a pluralistic secular society, any morality that does exist is loosely connected, lacks substantive moral content, is based on the ...
Laabs, Carolyn A.
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Fine particulate matter (PM2.5) is a possible trigger of systemic autoimmune rheumatic diseases (SARDs). We investigated SARDs risk related to long‐term exposure to PM2.5 and its components (ammonium, black carbon, mineral dust, sea salt, nitrate, sulfate, organic matter), the composition of which may affect toxicity.
Mareva Geslin +6 more
wiley +1 more source